Literature DB >> 26399212

Preventable but neglected: rickets in an informal settlement, Nairobi, Kenya.

J K Edwards1, A Thiongó1, R Van den Bergh2, W Kizito1, R J Kosgei3, A Sobry1, A Vandenbulcke1, I Zuniga4, A J Reid2.   

Abstract

SETTING: The primary care clinics of Médecins Sans Frontières within the informal settlement of Kibera, Nairobi, Kenya.
OBJECTIVE: To describe the demographic and clinical characteristics of children clinically diagnosed with rickets from September 2012 to October 2013.
DESIGN: Descriptive retrospective case review of diagnosis and treatment course with vitamin D and calcium using routine programme data.
RESULTS: Of the 82 children who met the clinical diagnosis of rickets, 57% were male, with a median age of 12 months and 14 months for females. Children with rickets were found to have ⩽3 hours/week sunlight exposure for 71% of the children and malnutrition in 39%. Clinical findings on presentation revealed gross motor developmental delays in 44%. The loss to follow-up rate during treatment was 40%.
CONCLUSIONS: This study found that rickets is a common clinical presentation among children living in the informal settlement of Kibera and that there are likely multiple factors within that environment contributing to this condition. As rickets is a simply and inexpensively preventable non-communicable disease, we suggest that routine vitamin D supplementation be formally recommended by the World Health Organization for well-child care in Africa, especially in the contexts of informal settlements.

Entities:  

Keywords:  World Health Organization; operational research; pediatric; vitamin D deficiency

Year:  2014        PMID: 26399212      PMCID: PMC4539038          DOI: 10.5588/pha.14.0009

Source DB:  PubMed          Journal:  Public Health Action        ISSN: 2220-8372


  23 in total

1.  The usefulness of clinical features to identify active rickets.

Authors:  Tom D Thacher; Philip R Fischer; John M Pettifor
Journal:  Ann Trop Paediatr       Date:  2002-09

2.  Caseload, management and treatment outcomes of patients with hypertension and/or diabetes mellitus in a primary health care programme in an informal setting.

Authors:  Agnes Sobry; Walter Kizito; Rafael Van den Bergh; Katie Tayler-Smith; Petros Isaakidis; Erastus Cheti; Rose J Kosgei; Alexandra Vandenbulcke; Zacharia Ndegwa; Tony Reid
Journal:  Trop Med Int Health       Date:  2014-01       Impact factor: 2.622

Review 3.  Geographic location and vitamin D synthesis.

Authors:  Michael G Kimlin
Journal:  Mol Aspects Med       Date:  2008-08-28

Review 4.  Vitamin D deficiency rickets in developing countries.

Authors:  Z A Karrar
Journal:  Ann Trop Paediatr       Date:  1998-09

5.  Prevention of nutritional rickets in Nigerian children with dietary calcium supplementation.

Authors:  Tom D Thacher; Philip R Fischer; Christian O Isichei; Ayuba I Zoakah; John M Pettifor
Journal:  Bone       Date:  2012-02-22       Impact factor: 4.398

6.  Photosynthesis of vitamin D in the skin: effect of environmental and life-style variables.

Authors:  M F Holick
Journal:  Fed Proc       Date:  1987-04

7.  Calcium deficiency and causation of rickets in Ethiopian children.

Authors:  T Belachew; H Nida; T Getaneh; D Woldemariam; W Getinet
Journal:  East Afr Med J       Date:  2005-03

Review 8.  Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease.

Authors:  Michael F Holick
Journal:  Am J Clin Nutr       Date:  2004-12       Impact factor: 7.045

9.  Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children.

Authors:  L Muhe; S Lulseged; K E Mason; E A Simoes
Journal:  Lancet       Date:  1997-06-21       Impact factor: 79.321

10.  Prevention of Vitamin D deficiency in infancy: daily 400 IU vitamin D is sufficient.

Authors:  Gul Yesiltepe Mutlu; Yusuf Kusdal; Elif Ozsu; Filiz M Cizmecioglu; Sukru Hatun
Journal:  Int J Pediatr Endocrinol       Date:  2011-06-28
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  4 in total

1.  Vitamin D deficiency causes rickets in an urban informal settlement in Kenya and is associated with malnutrition.

Authors:  Kelsey D J Jones; C Ulrich Hachmeister; Maureen Khasira; Lorna Cox; Inez Schoenmakers; Caroline Munyi; H Samira Nassir; Barbara Hünten-Kirsch; Ann Prentice; James A Berkley
Journal:  Matern Child Nutr       Date:  2017-05-03       Impact factor: 3.092

2.  The impact of rickets on growth and morbidity during recovery among children with complicated severe acute malnutrition in Kenya: A cohort study.

Authors:  Moses M Ngari; Johnstone Thitiri; Laura Mwalekwa; Molline Timbwa; Per Ole Iversen; Greg W Fegan; James A Berkley
Journal:  Matern Child Nutr       Date:  2017-11-27       Impact factor: 3.092

3.  Using data from a multi-hospital clinical network to explore prevalence of pediatric rickets in Kenya.

Authors:  Stella W Karuri; Maureen K Murithi; Grace Irimu; Mike English
Journal:  Wellcome Open Res       Date:  2017-11-01

4.  Nutritional rickets among children admitted with severe pneumonia at Mulago hospital, Uganda: a cross-sectional study.

Authors:  Thereza Piloya; Beatrice Odongkara; Edward Maloba Were; Faith Ameda; Edison Mworozi; Paul Laigong
Journal:  BMC Pediatr       Date:  2018-10-29       Impact factor: 2.125

  4 in total

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