Literature DB >> 26398773

Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors.

Thorsten A Kirschberg1, Michael Mish1, Neil H Squires1, Sebastian Zonte1, Evangelos Aktoudianakis1, Sammy Metobo1, Thomas Butler1, Xie Ju1, Aesop Cho1, Adrian S Ray1, Choung U Kim2.   

Abstract

Ribose modified 1'-C-cyano pyrimidine nucleosides were synthesized. A silver triflate mediated Vorbrüggen reaction was used to generate the nucleoside scaffold and follow-up chemistry provided specific ribose modified analogs. Nucleosides and phosphoramidate prodrugs were tested for their anti-HCV activity.

Entities:  

Keywords:  1′-cyano pyrimidine nucleosides; HCV; Nucleosides

Mesh：

Substances：

Year:  2015        PMID： 26398773     DOI： 10.1080/15257770.2015.1075550

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  1 in total

1.  Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.

Authors:  Dustin Siegel; Hon C Hui; Edward Doerffler; Michael O Clarke; Kwon Chun; Lijun Zhang; Sean Neville; Ernest Carra; Willard Lew; Bruce Ross; Queenie Wang; Lydia Wolfe; Robert Jordan; Veronica Soloveva; John Knox; Jason Perry; Michel Perron; Kirsten M Stray; Ona Barauskas; Joy Y Feng; Yili Xu; Gary Lee; Arnold L Rheingold; Adrian S Ray; Roy Bannister; Robert Strickley; Swami Swaminathan; William A Lee; Sina Bavari; Tomas Cihlar; Michael K Lo; Travis K Warren; Richard L Mackman
Journal:  J Med Chem       Date:  2017-02-14       Impact factor: 7.446
  1 in total

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