Literature DB >> 26398719

Role of the LKB1/AMPK pathway in tumor invasion and metastasis of cancer cells (Review).

Nianshuang Li1, Deqiang Huang1, Nonghua Lu1, Lingyu Luo1.   

Abstract

Liver kinase B1 (LKB1), also known as serine/threo-nine kinase 11 (STK11), is a tumor suppressor that is inactivated in Peutz-Jeghers familial cancer syndrome. LKB1 phosphorylates and activates AMP-activated protein kinase (AMPK), which negatively regulates cancer cell proliferation and metabolism. However, recent evidence demonstrates that the LKB1/AMPK pathway is involved in the process of tumor invasion and migration, which is an important hallmark of carcinoma progression to higher pathological grades of malignancy. This review focuses on the function of the LKB1/AMPK pathway in the invasion and migration of cancer cells and provides an overview of therapeutic strategies aimed at this pathway in malignant tumors.

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Year:  2015        PMID： 26398719     DOI： 10.3892/or.2015.4288

Source DB:  PubMed          Journal:  Oncol Rep        ISSN： 1021-335X            Impact factor:   3.906


  27 in total

Review 1.  MicroRNAs as Potential Targets for Therapeutic Intervention With Metastasis of Non-small Cell Lung Cancer.

Authors:  Ulrich H Weidle; Fabian Birzele; Adam Nopora
Journal:  Cancer Genomics Proteomics       Date:  2019 Mar-Apr       Impact factor: 4.069

Review 2.  Fumarate hydratase in cancer: A multifaceted tumour suppressor.

Authors:  Christina Schmidt; Marco Sciacovelli; Christian Frezza
Journal:  Semin Cell Dev Biol       Date:  2019-05-22       Impact factor: 7.727

Review 3.  Pathological implication of protein post-translational modifications in cancer.

Authors:  Sheng Pan; Ru Chen
Journal:  Mol Aspects Med       Date:  2022-04-07

4.  Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers.

Authors:  John D Hurley; Austin T Akers; Jamie R Friedman; Nicholas A Nolan; Kathleen C Brown; Piyali Dasgupta
Journal:  Cell Adh Migr       Date:  2016-05-19       Impact factor: 3.405

5.  Quercetin induces bladder cancer cells apoptosis by activation of AMPK signaling pathway.

Authors:  Qiongli Su; Mei Peng; Yuqing Zhang; Wanjun Xu; Kwame Oteng Darko; Ting Tao; Yanjun Huang; Xiaojun Tao; Xiaoping Yang
Journal:  Am J Cancer Res       Date:  2016-01-15       Impact factor: 6.166

6.  A meta-analysis of transcriptome datasets characterizes malignant transformation from melanocytes and nevi to melanoma.

Authors:  Daniel Ortega-Bernal; Claudia H González-De La Rosa; Elena Arechaga-Ocampo; Miguel Angel Alvarez-Avitia; Nora Sobrevilla Moreno; Claudia Rangel-Escareño
Journal:  Oncol Lett       Date:  2018-05-31       Impact factor: 2.967

7.  Phe354Leu Polymorphism of LKB1 Is a Potential Prognostic Factor for Cytogenetically Normal Acute Myeloid Leukemia.

Authors:  Ming-Yu Yang; Hui-Hua Hsiao; Yi-Chang Liu; Cheng-Ming Hsu; Sheng-Fung Lin; Pai-Mei Lin
Journal:  In Vivo       Date:  2017 Sep-Oct       Impact factor: 2.155

8.  Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer.

Authors:  Yunyun Chen; Anastasios Maniakas; Lin Tan; Meng Cui; Xiangdong Le; Joshua S Niedzielski; Keith A Michel; Collin J Harlan; Wuhao Lu; Ying C Henderson; Abdallah S R Mohamed; Philip L Lorenzi; Nagireddy Putluri; James A Bankson; Vlad C Sandulache; Stephen Y Lai
Journal:  Br J Cancer       Date:  2021-03-19       Impact factor: 9.075

9.  Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex.

Authors:  Tian Xia; Di Chen; Xiaolong Liu; Huan Qi; Wen Wang; Huan Chen; Ting Ling; Wuxiyar Otkur; Chen-Song Zhang; Jongchan Kim; Sheng-Cai Lin; Hai-Long Piao
Journal:  Cell Death Dis       Date:  2022-04-29       Impact factor: 9.685

10.  Metformin induces apoptosis of human hepatocellular carcinoma HepG2 cells by activating an AMPK/p53/miR-23a/FOXA1 pathway.

Authors:  Yunpeng Sun; Chonglin Tao; Xiaming Huang; Han He; Hongqi Shi; Qiyu Zhang; Huanhuan Wu
Journal:  Onco Targets Ther       Date:  2016-05-12       Impact factor: 4.147
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