| Literature DB >> 26398275 |
Jianqing Ruan1, Hong Gao2, Na Li1, Junyi Xue1,3, Jie Chen2, Changqiang Ke3,4, Yang Ye3,4, Peter Pi-Cheng Fu5, Jiang Zheng6,7, Jiyao Wang2, Ge Lin1,3.
Abstract
Pyrrolizidine alkaloids (PAs) induce liver injury (PA-ILI) and is very likely to contribute significantly to drug-induced liver injury (DILI). In this study we used a newly developed ultra-high performance liquid chromatography-triple quadrupole-mass spectrometry (UHPLC-MS)-based method to detect and quantitate blood pyrrole-protein adducts in DILI patients. Among the 46 suspected DILI patients, 15 were identified as PA-ILI by the identification of PA-containing herbs exposed. Blood pyrrole-protein adducts were detected in all PA-ILI patients (100%). These results confirm that PA-ILI is one of the major causes of DILI and that blood pyrrole-protein adducts quantitated by the newly developed UHPLC-MS method can serve as a specific biomarker of PA-ILI.Entities:
Keywords: hepatic sinusoidal obstruction syndrome; hepatotoxicity; pyrrole-protein adducts; pyrrolizidine alkaloids
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Year: 2015 PMID： 26398275 DOI： 10.1080/10590501.2015.1096882
Source DB: PubMed Journal: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev ISSN： 1059-0501 Impact factor: 3.781