Tracy R Luckhardt1, Victor J Thannickal. 1. aDivision of Pulmonary, Allergy and Critical Care Medicine bDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Abstract
PURPOSE OF REVIEW: Systemic sclerosis (SSc) is an autoimmune disease with fibrosis seen in multiple organs. Although not traditionally regarded as a disease of aging, SSc-associated fibrosis shares many of the hallmarks of aging seen in other age-related fibrotic disorders. Here, we review the current literature of the potential role of aging and age-related cellular processes in the development of SSc and fibrosis. RECENT FINDINGS: Accumulating evidence supports a role for immune dysregulation, epigenetic modifications, cellular senescence, mitochondrial dysregulation and impaired autophagy in fibrosis that occurs in aging and SSc. SUMMARY: Cellular alterations linked to aging may promote the development and/or progression of SSc-associated fibrosis.
PURPOSE OF REVIEW: Systemic sclerosis (SSc) is an autoimmune disease with fibrosis seen in multiple organs. Although not traditionally regarded as a disease of aging, SSc-associated fibrosis shares many of the hallmarks of aging seen in other age-related fibrotic disorders. Here, we review the current literature of the potential role of aging and age-related cellular processes in the development of SSc and fibrosis. RECENT FINDINGS: Accumulating evidence supports a role for immune dysregulation, epigenetic modifications, cellular senescence, mitochondrial dysregulation and impaired autophagy in fibrosis that occurs in aging and SSc. SUMMARY: Cellular alterations linked to aging may promote the development and/or progression of SSc-associated fibrosis.
Authors: Marta Bueno; Yen-Chun Lai; Yair Romero; Judith Brands; Claudette M St Croix; Christelle Kamga; Catherine Corey; Jose D Herazo-Maya; John Sembrat; Janet S Lee; Steve R Duncan; Mauricio Rojas; Sruti Shiva; Charleen T Chu; Ana L Mora Journal: J Clin Invest Date: 2014-12-22 Impact factor: 14.808
Authors: Avignat S Patel; Jin Woo Song; Sarah G Chu; Kenji Mizumura; Juan C Osorio; Ying Shi; Souheil El-Chemaly; Chun Geun Lee; Ivan O Rosas; Jack A Elias; Augustine M K Choi; Danielle Morse Journal: PLoS One Date: 2015-03-18 Impact factor: 3.240
Authors: Evan A Elko; J Matthew Mahoney; Pamela Vacek; Albert van der Vliet; Vikas Anathy; Jos L J L van der Velden; Yvonne M W Janssen-Heininger; David J Seward Journal: Free Radic Biol Med Date: 2019-07-14 Impact factor: 7.376
Authors: Marta Bueno; Anna Papazoglou; Eleanor Valenzi; Mauricio Rojas; Robert Lafyatis; Ana L Mora Journal: Curr Rheumatol Rep Date: 2020-06-19 Impact factor: 4.592
Authors: David P Sheppard; Jennifer E Iudicello; Erin E Morgan; Rujvi Kamat; Lindsay R Clark; Gunes Avci; Mark W Bondi; Steven Paul Woods Journal: J Neurovirol Date: 2017-03-20 Impact factor: 2.643
Authors: Anne E Wyman; Zahid Noor; Rita Fishelevich; Virginia Lockatell; Nirav G Shah; Nevins W Todd; Sergei P Atamas Journal: Am J Physiol Lung Cell Mol Physiol Date: 2017-04-06 Impact factor: 5.464
Authors: Jun Wei; Hongyan Zhu; Gabriel Lord; Mitra Bhattachayya; Brielle M Jones; Graham Allaway; Shyam S Biswal; Benjamin Korman; Roberta G Marangoni; Warren G Tourtellotte; John Varga Journal: Transl Res Date: 2016-12-09 Impact factor: 7.012
Authors: Meredith L Sosulski; Rafael Gongora; Carol Feghali-Bostwick; Joseph A Lasky; Cecilia G Sanchez Journal: J Gerontol A Biol Sci Med Sci Date: 2017-05-01 Impact factor: 6.053
Authors: T Guastafierro; M G Bacalini; A Marcoccia; D Gentilini; S Pisoni; A M Di Blasio; A Corsi; C Franceschi; D Raimondo; A Spanò; P Garagnani; F Bondanini Journal: Clin Epigenetics Date: 2017-08-30 Impact factor: 6.551