Literature DB >> 26395630

Suppression of ITGB4 Gene Expression in PC-3 Cells with Short Interfering RNA Induces Changes in the Expression of β-Integrins Associated with RGD-Receptors.

E N Knyazev1, K M Nyushko2, B Ya Alekseev2, T R Samatov1, M Yu Shkurnikov3,4.   

Abstract

We studied the effect of transfection of PC-3 prostate cancer cells with a plasmid encoding shRNA complimentary to a fragment of integrin β4 (ITGB4). The results attest to considerable changes in the transcriptome of transfected cells. For instance, compensatory changes in the expression of integrin family genes were found.

Entities:  

Keywords:  ITGB4; RNA interference; integrin; metastasizing; prostate cancer

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Year:  2015        PMID： 26395630     DOI： 10.1007/s10517-015-3011-9

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  2 in total

1.  LAMA4-Regulating miR-4274 and Its Host Gene SORCS2 Play a Role in IGFBP6-Dependent Effects on Phenotype of Basal-Like Breast Cancer.

Authors:  Maxim Shkurnikov; Sergey Nikulin; Stepan Nersisyan; Andrey Poloznikov; Shan Zaidi; Ancha Baranova; Udo Schumacher; Daniel Wicklein; Alexander Tonevitsky
Journal:  Front Mol Biosci       Date:  2019-11-08

2.  Transcriptome sequencing identifies genes associated with invasion of ovarian cancer.

Authors:  Xiandong Peng; Min Yu; Jiazhou Chen
Journal:  J Int Med Res       Date:  2020-09       Impact factor: 1.671
  2 in total

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