Jun Li1, Yongtao Wu2, Shu Zhang3, Jian Zhang4, Fanpu Ji5, Wangjun Bo6, Xiaoyan Guo7, Zongfang Li8. 1. National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: lijun123@mail.xjtu.edu.cn. 2. Department of General Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, 555 East Friendship Road, Xi'an 710054, Shaanxi Province, PR China. Electronic address: wuyongtao@163.com. 3. National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China; Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: drzhangshu@163.com. 4. National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China; Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: zhangjian-937@163.com. 5. National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: jifanpu1979@163.com. 6. National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: baishui09@sina.com. 7. National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: gxiaoyan5999@163.com. 8. National-local Joint Engineering Research Center of Biodiagnostics and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China; Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University College of Medicine, 157 West 5th Road, Xi'an 710004, Shaanxi Province, PR China. Electronic address: lzf2568@gmail.com.
Abstract
BACKGROUND/AIM: Inflammatory cytokines is a key point in the development of pathogenesis of SAP. Inflammatory mediators TNF-α and IL-6 are up-regulated in serum of patients with SAP and become good discriminators of SAP severity. MATERIALS AND METHODS: In this study, we investigated the treatment effectiveness of Baicalein on SAP rat model. Baicalein was intravenously injected immediately after SAP induction in rats. The mortality, histopathology score, ascites fluid volume, and pro-inflammatory cytokine production were evaluated at 12 h after SAP induction. RESULTS: Baicalein decreased the pancreatic histopathology score, reduced ascites fluid production, protected against pancreatic injury, and improved survival in rats with SAP. The serum IL-6 and TNF-α concentrations were also down-regulated by Baicalein. CONCLUSION: Baicalein demonstrated a well curative capability on rats with SAP. The mechanism may be alleviateing pancreatic injury and inhibiting pro-inflammatory cytokines expression.
BACKGROUND/AIM: Inflammatory cytokines is a key point in the development of pathogenesis of SAP. Inflammatory mediators TNF-α and IL-6 are up-regulated in serum of patients with SAP and become good discriminators of SAP severity. MATERIALS AND METHODS: In this study, we investigated the treatment effectiveness of Baicalein on SAPrat model. Baicalein was intravenously injected immediately after SAP induction in rats. The mortality, histopathology score, ascites fluid volume, and pro-inflammatory cytokine production were evaluated at 12 h after SAP induction. RESULTS:Baicalein decreased the pancreatic histopathology score, reduced ascites fluid production, protected against pancreatic injury, and improved survival in rats with SAP. The serum IL-6 and TNF-α concentrations were also down-regulated by Baicalein. CONCLUSION:Baicalein demonstrated a well curative capability on rats with SAP. The mechanism may be alleviateing pancreatic injury and inhibiting pro-inflammatory cytokines expression.