Ji-Woong Lee1, Eun-Ah Kim2, Francisco Otarola2, Esteban Morales2, Fei Yu3, Abdelmonem A Afifi4, Kouros Nouri-Mahdavi2, Joseph Caprioli2. 1. The Jules Stein Eye Institute David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California, United States 2Department of Ophthalmology, Pusan National University School of Medicine, Busan, South Korea. 2. The Jules Stein Eye Institute David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California, United States. 3. The Jules Stein Eye Institute David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, California, United States 3Department of Biostatistics, Jonathan and Karin Fielding School of Public Health at UCLA, Los Angeles, C. 4. Department of Biostatistics, Jonathan and Karin Fielding School of Public Health at UCLA, Los Angeles, California, United States.
Abstract
PURPOSE: We investigated the longitudinal relationships between the changes in neuroretinal rim area (RA) and the slow (SC) and fast (FC) components of visual field (VF) decay at various stages of glaucoma. METHODS: We divided 465 eyes of 338 patients into glaucoma suspect, and preperimetric, early, and moderate/advanced glaucoma. All patients had a minimum of 3 confocal scanning laser ophthalmoscopic examinations and 4 VF tests with follow-up of 4 or more years. A pointwise exponential regression was used to perform trend analyses on thresholds at each VF test location, which was partitioned into SC and FC. A mixed effects linear model was used to explore the associations of RA change with mean deviation (MD), visual field index (VFI), SC, and FC. RESULTS: Decreased RA was associated with lower mean threshold sensitivities of FC regardless of baseline severity of glaucoma (P ≤ 0.03). The mean threshold sensitivities in SC were not correlated with RA change at any stage. Decreased RA was correlated with worse MD in preperimetric, early, and moderate/advanced glaucoma (P < 0.05). Decreased RA was correlated with worse VFI in preperimetric and early glaucoma only (P ≤ 0.04). CONCLUSIONS: A decrease in rim area was significantly correlated with the fast VF component regardless of the baseline severity of glaucoma. Mean deviation and VFI correlated with change of rim area only in certain stages of glaucoma. The identification of the fast component seems a more robust and useful measure of glaucomatous change than MD or VFI.
PURPOSE: We investigated the longitudinal relationships between the changes in neuroretinal rim area (RA) and the slow (SC) and fast (FC) components of visual field (VF) decay at various stages of glaucoma. METHODS: We divided 465 eyes of 338 patients into glaucoma suspect, and preperimetric, early, and moderate/advanced glaucoma. All patients had a minimum of 3 confocal scanning laser ophthalmoscopic examinations and 4 VF tests with follow-up of 4 or more years. A pointwise exponential regression was used to perform trend analyses on thresholds at each VF test location, which was partitioned into SC and FC. A mixed effects linear model was used to explore the associations of RA change with mean deviation (MD), visual field index (VFI), SC, and FC. RESULTS: Decreased RA was associated with lower mean threshold sensitivities of FC regardless of baseline severity of glaucoma (P ≤ 0.03). The mean threshold sensitivities in SC were not correlated with RA change at any stage. Decreased RA was correlated with worse MD in preperimetric, early, and moderate/advanced glaucoma (P < 0.05). Decreased RA was correlated with worse VFI in preperimetric and early glaucoma only (P ≤ 0.04). CONCLUSIONS: A decrease in rim area was significantly correlated with the fast VF component regardless of the baseline severity of glaucoma. Mean deviation and VFI correlated with change of rim area only in certain stages of glaucoma. The identification of the fast component seems a more robust and useful measure of glaucomatous change than MD or VFI.
Authors: Vahid Mohammadzadeh; Alessandro Rabiolo; Qiang Fu; Esteban Morales; Anne L Coleman; Simon K Law; Joseph Caprioli; Kouros Nouri-Mahdavi Journal: Ophthalmology Date: 2020-01-22 Impact factor: 12.079
Authors: Ricardo Y Abe; Alberto Diniz-Filho; Linda M Zangwill; Carolina P B Gracitelli; Amir H Marvasti; Robert N Weinreb; Saif Baig; Felipe A Medeiros Journal: Invest Ophthalmol Vis Sci Date: 2016-07-01 Impact factor: 4.799