Literature DB >> 26392990

Xpert(®) MTB/RIF under routine conditions in diagnosing pulmonary tuberculosis: a study in two hospitals in Pakistan.

S K Shah1, A M V Kumar2, O F Dogar1, M A Khan3, E Qadeer4, S Tahseen4, F Masood4, A K Chandio5, M E Edginton6.   

Abstract

Xpert(®) MTB/RIF testing was offered to consecutive patients with presumptive tuberculosis (TB) attending two hospitals in Pakistan during April-May 2012, in addition to routine diagnostic protocol (smear microscopy, chest radiography and clinical judgement). We assessed the relative contribution of each tool in detecting pulmonary TB under routine conditions. Of 606 participants, 121 (20%) were detected as pulmonary TB: 46 (38%) by microscopy, 38 (31%) by Xpert alone and 37 (31%) on clinical and radiological grounds; 41 (65%) were detected by both Xpert and microscopy. One patient had rifampicin resistance. Although Xpert detected approximately twice as many TB cases as microscopy (n = 79, 65%), clinical judgement remained favoured by clinicians even when smear and Xpert were negative.

Entities:  

Keywords:  Pakistan; Xpert MTB/RIF; diagnosis; operational research; tuberculosis

Year:  2013        PMID： 26392990      PMCID： PMC4463089          DOI： 10.5588/pha.12.0081

Source DB:  PubMed          Journal:  Public Health Action        ISSN： 2220-8372


  4 in total

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Journal:  N Engl J Med       Date:  2010-09-01       Impact factor: 91.245

4.  Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study.

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2.  For better or worse, microscopy is here to stay….

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  4 in total

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