Literature DB >> 26392489

Role of Semen on Vaginal HIV-1 Transmission and Maraviroc Protection.

Olivia D Council1, Michael D Swanson1, Rae Ann Spagnuolo1, Angela Wahl2, J Victor Garcia2.   

Abstract

We used bone marrow/liver/thymus (BLT) humanized mice to establish the effect of semen on vaginal HIV infection and on the efficacy of topically applied maraviroc. Our results demonstrate that vaginal transmission of cell-free HIV occurs efficiently in the presence of semen and that topically applied maraviroc efficiently prevents HIV transmission in the presence of semen. We also show that semen has no significant effect on the transmission of transmitted/founder viruses or cell-associated viruses.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26392489      PMCID： PMC4649249          DOI： 10.1128/AAC.01496-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

1.  DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.

Authors:  T B Geijtenbeek; D S Kwon; R Torensma; S J van Vliet; G C van Duijnhoven; J Middel; I L Cornelissen; H S Nottet; V N KewalRamani; D R Littman; C G Figdor; Y van Kooyk
Journal:  Cell       Date:  2000-03-03       Impact factor: 41.582

2.  Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides.

Authors:  Onofrio Zirafi; Kyeong-Ae Kim; Nadia R Roan; Silvia F Kluge; Janis A Müller; Shibo Jiang; Benjamin Mayer; Warner C Greene; Frank Kirchhoff; Jan Münch
Journal:  Sci Transl Med       Date:  2014-11-12       Impact factor: 17.956

Review 3.  Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice.

Authors:  Paul W Denton; J Victor Garcia
Journal:  Trends Microbiol       Date:  2012-04-12       Impact factor: 17.079

4.  Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages.

Authors:  Christina Ochsenbauer; Tara G Edmonds; Haitao Ding; Brandon F Keele; Julie Decker; Maria G Salazar; Jesus F Salazar-Gonzalez; Robin Shattock; Barton F Haynes; George M Shaw; Beatrice H Hahn; John C Kappes
Journal:  J Virol       Date:  2011-12-21       Impact factor: 5.103

Review 5.  Humanized mouse models of HIV infection.

Authors:  Paul W Denton; J Víctor García
Journal:  AIDS Rev       Date:  2011 Jul-Sep       Impact factor: 2.500

Review 6.  Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection.

Authors:  Rikke Olesen; Angela Wahl; Paul W Denton; J Victor Garcia
Journal:  J Reprod Immunol       Date:  2011-01-21       Impact factor: 4.054

7.  One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.

Authors:  Paul W Denton; Florence Othieno; Francisco Martinez-Torres; Wei Zou; John F Krisko; Elisa Fleming; Sima Zein; Daniel A Powell; Angela Wahl; Youn Tae Kwak; Brett D Welch; Michael S Kay; Deborah A Payne; Philippe Gallay; Ettore Appella; Jacob D Estes; Min Lu; J Victor Garcia
Journal:  J Virol       Date:  2011-05-18       Impact factor: 5.103

8.  Human breast milk and antiretrovirals dramatically reduce oral HIV-1 transmission in BLT humanized mice.

Authors:  Angela Wahl; Michael D Swanson; Tomonori Nochi; Rikke Olesen; Paul W Denton; Morgan Chateau; J Victor Garcia
Journal:  PLoS Pathog       Date:  2012-06-14       Impact factor: 6.823

9.  A topical microbicide gel formulation of CCR5 antagonist maraviroc prevents HIV-1 vaginal transmission in humanized RAG-hu mice.

Authors:  C Preston Neff; Theresa Kurisu; Thomas Ndolo; Kami Fox; Ramesh Akkina
Journal:  PLoS One       Date:  2011-06-01       Impact factor: 3.240

10.  Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection.

Authors:  Jesus F Salazar-Gonzalez; Maria G Salazar; Brandon F Keele; Gerald H Learn; Elena E Giorgi; Hui Li; Julie M Decker; Shuyi Wang; Joshua Baalwa; Matthias H Kraus; Nicholas F Parrish; Katharina S Shaw; M Brad Guffey; Katharine J Bar; Katie L Davis; Christina Ochsenbauer-Jambor; John C Kappes; Michael S Saag; Myron S Cohen; Joseph Mulenga; Cynthia A Derdeyn; Susan Allen; Eric Hunter; Martin Markowitz; Peter Hraber; Alan S Perelson; Tanmoy Bhattacharya; Barton F Haynes; Bette T Korber; Beatrice H Hahn; George M Shaw
Journal:  J Exp Med       Date:  2009-06-01       Impact factor: 14.307
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  10 in total

1.  HIV pre-exposure prophylaxis for women and infants prevents vaginal and oral HIV transmission in a preclinical model of HIV infection.

Authors:  Martina Kovarova; Uma Shanmugasundaram; Caroline E Baker; Rae Ann Spagnuolo; Chandrav De; Christopher C Nixon; Angela Wahl; J Victor Garcia
Journal:  J Antimicrob Chemother       Date:  2016-08-01       Impact factor: 5.790

Review 2.  Structure, function and antagonism of semen amyloids.

Authors:  Annika Röcker; Nadia R Roan; Jay Kant Yadav; Marcus Fändrich; Jan Münch
Journal:  Chem Commun (Camb)       Date:  2018-07-05       Impact factor: 6.222

3.  Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model.

Authors:  Angela Wahl; Phong T Ho; Paul W Denton; Katy L Garrett; Michael G Hudgens; Glenn Swartz; Cynthia O'Neill; Fulvia Veronese; Angela D Kashuba; J Victor Garcia
Journal:  Sci Rep       Date:  2017-02-01       Impact factor: 4.379

4.  Tracking Human Immunodeficiency Virus-1 Infection in the Humanized DRAG Mouse Model.

Authors:  Jiae Kim; Kristina K Peachman; Ousman Jobe; Elaine B Morrison; Atef Allam; Linda Jagodzinski; Sofia A Casares; Mangala Rao
Journal:  Front Immunol       Date:  2017-10-27       Impact factor: 7.561

Review 5.  Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies.

Authors:  Yash Agarwal; Cole Beatty; Shivkumar Biradar; Isabella Castronova; Sara Ho; Kevin Melody; Moses Turkle Bility
Journal:  Retrovirology       Date:  2020-04-10       Impact factor: 4.602

Review 6.  Advances in Humanized Mouse Models to Improve Understanding of HIV-1 Pathogenesis and Immune Responses.

Authors:  Amy Gillgrass; Jocelyn M Wessels; Jack X Yang; Charu Kaushic
Journal:  Front Immunol       Date:  2021-03-05       Impact factor: 7.561

7.  In vivo analysis of the effect of panobinostat on cell-associated HIV RNA and DNA levels and latent HIV infection.

Authors:  Perry Tsai; Guoxin Wu; Caroline E Baker; William O Thayer; Rae Ann Spagnuolo; Rosa Sanchez; Stephanie Barrett; Bonnie Howell; David Margolis; Daria J Hazuda; Nancie M Archin; J Victor Garcia
Journal:  Retrovirology       Date:  2016-05-21       Impact factor: 4.602

Review 8.  Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes.

Authors:  Fernando Notario-Pérez; Roberto Ruiz-Caro; María-Dolores Veiga-Ochoa
Journal:  Drug Des Devel Ther       Date:  2017-06-15       Impact factor: 4.162

9.  Ultra-long-acting removable drug delivery system for HIV treatment and prevention.

Authors:  Martina Kovarova; S Rahima Benhabbour; Ivana Massud; Rae Ann Spagnuolo; Brianna Skinner; Caroline E Baker; Craig Sykes; Katie R Mollan; Angela D M Kashuba; J Gerardo García-Lerma; Russell J Mumper; J Victor Garcia
Journal:  Nat Commun       Date:  2018-10-08       Impact factor: 14.919

10.  Detection of the Middle East respiratory syndrome coronavirus in dromedary camel's seminal plasma in Saudi Arabia 2015-2017.

Authors:  Maged Gomaa Hemida; Magdi Waheed; Ali M Ali; Abdelmohsen Alnaeem
Journal:  Transbound Emerg Dis       Date:  2020-05-22       Impact factor: 4.521
  10 in total

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