Sang-Ahm Lee1, Joon-Hyun Paek2, Su-Hyun Han2, Han-Uk Ryu3. 1. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address: salee@amc.seoul.kr. 2. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 3. Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; Department of Neurology, Chonbuk National University Medical School, Jeonju, Republic of Korea.
Abstract
PURPOSE: To explore the utility of a Korean version of the rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ-K) to discriminate patients with idiopathic REM sleep behavior disorder (iRBD) from patients with obstructive sleep apnea (OSA) and healthy subjects. METHODS: Participants with iRBD (n=47) and OSA (n=213) were diagnosed by polysomnography. In healthy subjects (n=58), RBD was excluded by medical history without polysomnography. Receiver operating characteristic curve analysis was used to identify the optimal cutoff value of the RBDSQ-K for iRBD. RESULTS: RBDSQ-K score was higher in iRBD subjects than in OSA subjects and healthy subjects (both p<0.001). The optimal cutoff was 6.5 to distinguish iRBD subjects from OSA subjects and 4.5 to distinguish iRBD subjects from healthy subjects. The corresponding sensitivity and specificity was high for detecting iRBD from OSA and healthy subjects. The percentages of individuals with RBDSQ-K scores ≥5 and ≥7 were higher in OSA subjects with daytime sleepiness (36.1% and 13.8%, respectively) than in OSA subjects without daytime sleepiness (12.0% and 3.1%, respectively). Apnea-hypopnea index had no influence on RBDSQ-K score. Cronbach's alpha for the RBDSQ-K was 0.768, indicating a high degree of internal consistency. CONCLUSIONS: The RBDSQ-K had acceptable sensitivity and specificity for screening persons with probable RBD from healthy subjects and OSA subjects when the cutoff score was 4.5 and 6.5 points, respectively. However, attention must be paid to the possibility of false positives when using this scale, especially in OSA subjects with daytime sleepiness.
PURPOSE: To explore the utility of a Korean version of the rapid eye movement sleep behavior disorder screening questionnaire (RBDSQ-K) to discriminate patients with idiopathic REM sleep behavior disorder (iRBD) from patients with obstructive sleep apnea (OSA) and healthy subjects. METHODS:Participants with iRBD (n=47) and OSA (n=213) were diagnosed by polysomnography. In healthy subjects (n=58), RBD was excluded by medical history without polysomnography. Receiver operating characteristic curve analysis was used to identify the optimal cutoff value of the RBDSQ-K for iRBD. RESULTS: RBDSQ-K score was higher in iRBD subjects than in OSA subjects and healthy subjects (both p<0.001). The optimal cutoff was 6.5 to distinguish iRBD subjects from OSA subjects and 4.5 to distinguish iRBD subjects from healthy subjects. The corresponding sensitivity and specificity was high for detecting iRBD from OSA and healthy subjects. The percentages of individuals with RBDSQ-K scores ≥5 and ≥7 were higher in OSA subjects with daytime sleepiness (36.1% and 13.8%, respectively) than in OSA subjects without daytime sleepiness (12.0% and 3.1%, respectively). Apnea-hypopnea index had no influence on RBDSQ-K score. Cronbach's alpha for the RBDSQ-K was 0.768, indicating a high degree of internal consistency. CONCLUSIONS: The RBDSQ-K had acceptable sensitivity and specificity for screening persons with probable RBD from healthy subjects and OSA subjects when the cutoff score was 4.5 and 6.5 points, respectively. However, attention must be paid to the possibility of false positives when using this scale, especially in OSA subjects with daytime sleepiness.
Authors: Ji Hyun Choi; Jee Young Lee; Jin Whan Cho; Seong Beom Ko; Tae Beom Ahn; Sang Jin Kim; Sang Myung Cheon; Joong Seok Kim; Yoon Joong Kim; Hyeo Il Ma; Jong Sam Baik; Phil Hyu Lee; Sun Ju Chung; Jong Min Kim; In Uk Song; Han Joon Kim; Young Hee Sung; Do Young Kwon; Jae Hyeok Lee; Ji Young Kim; Ji Sun Kim; Ji Young Yun; Hee Jin Kim; Jin Yong Hong; Mi Jung Kim; Jinyoung Youn; Ji Seon Kim; Eung Seok Oh; Hui Jun Yang; Won Tae Yoon; Sooyeoun You; Kyum Yil Kwon; Hyung Eun Park; Su Yun Lee; Younsoo Kim; Hee Tae Kim; Mee Young Park Journal: J Clin Neurol Date: 2020-04 Impact factor: 3.077
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