Literature DB >> 26392113

HEPACAM inhibited the growth and migration of cancer cells in the progression of non-small cell lung cancer.

Huanzhang Shao1, Yinjie Gu2, Junli Ding3, Peihua Lu3, Tingyan Ruan3, Wenbin Lu4.   

Abstract

Hepatocyte cell adhesion molecule (HEPACAM), a member of immunoglobulin superfamily, is an adhesion molecule. Although dysregulation of several adhesion molecules has been implicated in the progression of non-small cell lung cancer (NSCLC), the expression profile and functions of HEPACAM in NSCLC remains unknown. In this study, it was found that the expression of HEPACAM was downregulated in NSCLC tissues. Forced expression of HEPACAM in NSCLC cells inhibited the growth and migration of the cancer cells, while knocking down the expression of HEPACAM promoted cell growth, migration, and metastasis. In the molecular mechanism study, HEPACAM was found to be a negative regulator of beta-catenin/TCF signaling. Taken together, this study revealed the suppressive roles of HEPACAM in NSCLC and restoring the function of HEPACAM in NSCLC might be a promising strategy for the therapy.

Entities:  

Keywords:  Beta-catenin/TCF; Cell growth and migration; HEPACAM; Non-small cell lung cancer

Mesh：

Substances：

Year:  2015        PMID： 26392113     DOI： 10.1007/s13277-015-4084-9

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  22 in total

1.  Expression of hepaCAM is downregulated in cancers and induces senescence-like growth arrest via a p53/p21-dependent pathway in human breast cancer cells.

Authors:  Mei Chung Moh; Ting Zhang; Lay Hoon Lee; Shali Shen
Journal:  Carcinogenesis       Date:  2008-10-08       Impact factor: 4.944

2.  The clinicopathological significance and potential drug target of E-cadherin in NSCLC.

Authors:  Kaize Zhong; Weiwen Chen; Ning Xiao; Jian Zhao
Journal:  Tumour Biol       Date:  2015-03-11

3.  Inhibition of β-Catenin enhances the anticancer effect of irreversible EGFR-TKI in EGFR-mutated non-small-cell lung cancer with a T790M mutation.

Authors:  Yosuke Togashi; Hidetoshi Hayashi; Masato Terashima; Marco A de Velasco; Kazuko Sakai; Yoshihiko Fujita; Shuta Tomida; Kazuhiko Nakagawa; Kazuto Nishio
Journal:  J Thorac Oncol       Date:  2015-01       Impact factor: 15.609

4.  Choroidal metastasis response to crizotinib in a ROS1-rearranged NSCLC patient.

Authors:  Stephanie Lu; Michele C Azada; Sai-Hong Ignatius Ou
Journal:  Lung Cancer       Date:  2014-12-19       Impact factor: 5.705

5.  The immunoglobulin-like cell adhesion molecule hepaCAM is cleaved in the human breast carcinoma MCF7 cells.

Authors:  Ting Zhang; Mei C Moh; Lay H Lee; Shali Shen
Journal:  Int J Oncol       Date:  2010-07       Impact factor: 5.650

6.  Overexpression of HepaCAM inhibits cell viability and motility through suppressing nucleus translocation of androgen receptor and ERK signaling in prostate cancer.

Authors:  Xuedong Song; Yin Wang; Hongfei Du; Yanru Fan; Xue Yang; Xiaorong Wang; Xiaohou Wu; Chunli Luo
Journal:  Prostate       Date:  2014-05-08       Impact factor: 4.104

7.  The immunoglobulin-like cell adhesion molecule hepaCAM induces differentiation of human glioblastoma U373-MG cells.

Authors:  Lay Hoon Lee; Mei Chung Moh; Ting Zhang; Shali Shen
Journal:  J Cell Biochem       Date:  2009-08-15       Impact factor: 4.429

8.  Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways.

Authors:  Dong Xie; Dong Yin; Xiangjun Tong; James O'Kelly; Akio Mori; Carl Miller; Keith Black; Dorina Gui; Johathan W Said; H Phillip Koeffler
Journal:  Cancer Res       Date:  2004-03-15       Impact factor: 12.701

Review 9.  GlialCAM, a glial cell adhesion molecule implicated in neurological disease.

Authors:  Alejandro Barrallo-Gimeno; Raúl Estévez
Journal:  Adv Neurobiol       Date:  2014

10.  Identification of hypermethylation in hepatocyte cell adhesion molecule gene promoter region in bladder carcinoma.

Authors:  Jia Tao; Qi Liu; Xiaohou Wu; Xin Xu; Yanyi Zhang; Qiuju Wang; Chunli Luo
Journal:  Int J Med Sci       Date:  2013-11-11       Impact factor: 3.738
View more
  5 in total

1.  Label-free Proteomic Analysis of Exosomes Derived from Inducible Hepatitis B Virus-Replicating HepAD38 Cell Line.

Authors:  Xiaofang Jia; Jieliang Chen; Dominik A Megger; Xiaonan Zhang; Maya Kozlowski; Lijun Zhang; Zhong Fang; Jin Li; Qiaofang Chu; Min Wu; Yaming Li; Barbara Sitek; Zhenghong Yuan
Journal:  Mol Cell Proteomics       Date:  2017-02-27       Impact factor: 5.911

2.  Comprehensive molecular biomarker identification in breast cancer brain metastases.

Authors:  Hans-Juergen Schulten; Mohammed Bangash; Sajjad Karim; Ashraf Dallol; Deema Hussein; Adnan Merdad; Fatma K Al-Thoubaity; Jaudah Al-Maghrabi; Awatif Jamal; Fahad Al-Ghamdi; Hani Choudhry; Saleh S Baeesa; Adeel G Chaudhary; Mohammed H Al-Qahtani
Journal:  J Transl Med       Date:  2017-12-29       Impact factor: 5.531

3.  HepaCAM associates with connexin 43 and enhances its localization in cellular junctions.

Authors:  Meihui Wu; Mei Chung Moh; Herbert Schwarz
Journal:  Sci Rep       Date:  2016-11-07       Impact factor: 4.379

4.  Extracellular AGR3 regulates breast cancer cells migration via Src signaling.

Authors:  Joanna Obacz; Lucia Sommerova; Daria Sicari; Michal Durech; Tony Avril; Filippo Iuliano; Silvia Pastorekova; Roman Hrstka; Eric Chevet; Frederic Delom; Delphine Fessart
Journal:  Oncol Lett       Date:  2019-09-10       Impact factor: 2.967

5.  Transcriptome Related to Avoiding Immune Destruction in Nasopharyngeal Cancer in Indonesian Patients Using Next-Generation Sequencing.

Authors:  Risky Hiskia Poluan; Digdo Sudigyo; Gisti Rahmawati; Dicka Wahyu Setiasari; Salsabila Luthfi Sesotyosari; Tirta Wardana; Indwiani Astuti; Didik Setyo Heriyanto; Sagung Rai Indrasari; Cita Herawati; - Afiahayati; Sofia Mubarika Haryana
Journal:  Asian Pac J Cancer Prev       Date:  2020-09-01
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.