R Shane Tubbs1,2, Annie Laurie Benzie3, Elias Rizk4, Joshua J Chern5, Marios Loukas6, W Jerry Oakes7. 1. Seattle Science Foundation, Seattle, WA, USA. shane.tubbs@childrensal.org. 2. , 1600 7th Ave S, Birmingham, AL, 35233, USA. shane.tubbs@childrensal.org. 3. Department of Surgery, New York Methodist Hospital, Brooklyn, NY, USA. 4. Neurological Surgery, Penn State Hershey Medical Center, Hershey, PA, USA. 5. Pediatric Neurosurgery Associates, Children's Healthcare of Atlanta, Atlanta, USA. 6. Department of Anatomical Sciences, St. George's University, St. George's, Grenada. 7. Pediatric Neurosurgery, Children's of Alabama, Birmingham, AL, USA.
Abstract
BACKGROUND: This study is focused on the histologic characteristics of occipital bone removed during Chiari I decompression in the hope of discovering unique features that may be related to the pathogenesis of this condition. METHODS: Ten consecutive pediatric patients with Chiari I malformation underwent standard posterior fossa decompression surgery. Bone that was removed from the posterior fossa was sent for histological examination. Bone from age-matched controls also underwent histological analysis. RESULTS: For all study and control specimens, bony samples were found to be made up of dense lamellar bone without marrow elements. In all aspects, histologically, the bone tissue had a normal appearance compared to control samples. CONCLUSIONS: Although many authors have mentioned that the occipital bone in patients with Chiari I malformation is abnormal on imaging or at operation (e.g., thinned, thickened), based on our study, there is no histological difference between the occipital bone removed at operation and controls.
BACKGROUND: This study is focused on the histologic characteristics of occipital bone removed during Chiari I decompression in the hope of discovering unique features that may be related to the pathogenesis of this condition. METHODS: Ten consecutive pediatric patients with Chiari I malformation underwent standard posterior fossa decompression surgery. Bone that was removed from the posterior fossa was sent for histological examination. Bone from age-matched controls also underwent histological analysis. RESULTS: For all study and control specimens, bony samples were found to be made up of dense lamellar bone without marrow elements. In all aspects, histologically, the bone tissue had a normal appearance compared to control samples. CONCLUSIONS: Although many authors have mentioned that the occipital bone in patients with Chiari I malformation is abnormal on imaging or at operation (e.g., thinned, thickened), based on our study, there is no histological difference between the occipital bone removed at operation and controls.
Authors: R Shane Tubbs; Christoph J Griessenauer; Philipp Hendrix; Peter Oakes; Marios Loukas; Joshua J Chern; Curtis J Rozzelle; W Jerry Oakes Journal: Clin Anat Date: 2015-05-14 Impact factor: 2.414
Authors: R Shane Tubbs; Joshua Beckman; Robert P Naftel; Joshua J Chern; John C Wellons; Curtis J Rozzelle; Jeffrey P Blount; W Jerry Oakes Journal: J Neurosurg Pediatr Date: 2011-03 Impact factor: 2.375
Authors: R Shane Tubbs; Daniel Webb; Hussein Abdullatif; Michael Conklin; Scott Doyle; W Jerry Oakes Journal: Neurosurgery Date: 2004-08 Impact factor: 4.654
Authors: R Shane Tubbs; John C Wellons; Matthew D Smyth; Alfred A Bartolucci; Jeffrey P Blount; W Jerry Oakes; Paul A Grabb Journal: Pediatr Neurosurg Date: 2003-06 Impact factor: 1.162