PURPOSE: To evaluate the effect of diabetes mellitus (DM) on central corneal thickness (CCT), corneal endothelial parameters (endothelial cell density [ECD], average size [AVE], hexagonality [A6], polymegathism [SD]), and subfoveal choroidal thickness (SFCT), and to determine whether these parameters depend on the duration of DM and hemoglobin A1c (HbA1c) level. METHODS: A total of 62 patients with type 2 DM and 65 healthy subjects were examined using a noncontact specular microscope, A-scan ultrasound, and spectral-domain optical coherence tomography. The study parameters included medical history, age, eye axial length, CCT, ECD, AVE, A6, SD, and SFCT. The duration of DM and HbA1c level of the 2 latest tests were noted. RESULTS: The SFCT (258.0 ± 74.4 µm) and ECD (2721.8 ± 264.1 cells/mm2) were significantly lower, and the CCT (566.7 ± 35.7 µm) higher, in diabetic patients than in the control group (313.1 ± 88.5 µm, 2967.3 ± 220.6 cells/mm2, 550.0 ± 56.4 µm, respectively) (p<0.05). There were no differences in age, sex, or axial length between the diabetic and control groups (p>0.05). Diabetic retinopathy and macular edema did not influence SFCT significantly (p>0.05). No differences in endothelial parameters between groups and no correlations among HbA1c, duration of DM, and any of the examined parameters were found (p>0.05). CONCLUSIONS: Diabetic patients have thicker corneas, lower ECD, and thinner subfoveal choroid than healthy subjects.
PURPOSE: To evaluate the effect of diabetes mellitus (DM) on central corneal thickness (CCT), corneal endothelial parameters (endothelial cell density [ECD], average size [AVE], hexagonality [A6], polymegathism [SD]), and subfoveal choroidal thickness (SFCT), and to determine whether these parameters depend on the duration of DM and hemoglobin A1c (HbA1c) level. METHODS: A total of 62 patients with type 2 DM and 65 healthy subjects were examined using a noncontact specular microscope, A-scan ultrasound, and spectral-domain optical coherence tomography. The study parameters included medical history, age, eye axial length, CCT, ECD, AVE, A6, SD, and SFCT. The duration of DM and HbA1c level of the 2 latest tests were noted. RESULTS: The SFCT (258.0 ± 74.4 µm) and ECD (2721.8 ± 264.1 cells/mm2) were significantly lower, and the CCT (566.7 ± 35.7 µm) higher, in diabeticpatients than in the control group (313.1 ± 88.5 µm, 2967.3 ± 220.6 cells/mm2, 550.0 ± 56.4 µm, respectively) (p&lt;0.05). There were no differences in age, sex, or axial length between the diabetic and control groups (p&gt;0.05). Diabetic retinopathy and macular edema did not influence SFCT significantly (p&gt;0.05). No differences in endothelial parameters between groups and no correlations among HbA1c, duration of DM, and any of the examined parameters were found (p&gt;0.05). CONCLUSIONS:Diabeticpatients have thicker corneas, lower ECD, and thinner subfoveal choroid than healthy subjects.
Authors: Navasuja Kumar; Rodica Pop-Busui; David C Musch; David M Reed; Anna C Momont; Munira Hussain; Nilesh Raval; Sayoko E Moroi; Roni Shtein Journal: Cornea Date: 2018-09 Impact factor: 2.651
Authors: João N Beato; João Esteves-Leandro; David Reis; Manuel Falcão; Vítor Rosas; Ângela Carneiro; Fernando Falcão Reis Journal: Clin Ophthalmol Date: 2020-07-14
Authors: Fang Zheng; Giovanni Gregori; Karen B Schaal; Andrew D Legarreta; Andrew R Miller; Luiz Roisman; William J Feuer; Philip J Rosenfeld Journal: Invest Ophthalmol Vis Sci Date: 2016-11-01 Impact factor: 4.799
Authors: Joanna Gołębiewska; Andrzej Olechowski; Marta Wysocka-Mincewicz; Marta Baszyńska-Wilk; Artur Groszek; Agnieszka Czeszyk-Piotrowicz; Mieczysław Szalecki; Wojciech Hautz Journal: J Diabetes Res Date: 2018-04-03 Impact factor: 4.011