Toshiyuki Irie1. 1. Department of Radiology, Hitachi General Hospital, Jyonann 2-1-1, Hitachi, Ibaraki, 317-0077, Japan. toshiyuki.irie.rq@gmail.com.
Abstract
PURPOSE: Spherical porous gelatin particles (Gelpart(®), Nippon Kayaku, Tokyo) were crushed by a pumping method to create small gelatin particles for transarterial chemoembolization of hepatocellular carcinoma. The aim of this study was to analyze crushed particle size. MATERIALS AND METHODS: To minimize the size of crushed particles, we used the pumping method using two 2.5-mL syringes connected by a 3-way stopcock. Sixteen samples created by 3 operators were examined. The crushed particles were stained with hematoxylin-eosin, images magnified by a microscope were captured using a digital camera, and the maximum length of each particle was measured. The differences in particle size within the same operator and among the 3 operators were examined by an ANOVA test. RESULTS: The particle sizes created by each operator were 139.0 ± 58.8, 201.1 ± 90.9, and 158.4 ± 72.0 µm, respectively. There was a statistically significant difference in particle size among the 3 operators (p < 0.01). With one operator, there was no statistically significant difference in the particle size among the 4 samples (p = 0.93). With 2 operators, there were statistically significant differences among 5, or 7 samples, respectively (p < 0.01). CONCLUSION: Small gelatin particles can be created with Gelpart(®) by the pumping method, but mean particle size was different among samples and not reproducible.
PURPOSE: Spherical porous gelatin particles (Gelpart(®), Nippon Kayaku, Tokyo) were crushed by a pumping method to create small gelatin particles for transarterial chemoembolization of hepatocellular carcinoma. The aim of this study was to analyze crushed particle size. MATERIALS AND METHODS: To minimize the size of crushed particles, we used the pumping method using two 2.5-mL syringes connected by a 3-way stopcock. Sixteen samples created by 3 operators were examined. The crushed particles were stained with hematoxylin-eosin, images magnified by a microscope were captured using a digital camera, and the maximum length of each particle was measured. The differences in particle size within the same operator and among the 3 operators were examined by an ANOVA test. RESULTS: The particle sizes created by each operator were 139.0 ± 58.8, 201.1 ± 90.9, and 158.4 ± 72.0 µm, respectively. There was a statistically significant difference in particle size among the 3 operators (p < 0.01). With one operator, there was no statistically significant difference in the particle size among the 4 samples (p = 0.93). With 2 operators, there were statistically significant differences among 5, or 7 samples, respectively (p < 0.01). CONCLUSION: Small gelatin particles can be created with Gelpart(®) by the pumping method, but mean particle size was different among samples and not reproducible.
Authors: Mary A Maluccio; Anne M Covey; Leah Ben Porat; Joanna Schubert; Lynn A Brody; Constantinos T Sofocleous; George I Getrajdman; William Jarnagin; Ronald Dematteo; Leslie H Blumgart; Yuman Fong; Karen T Brown Journal: J Vasc Interv Radiol Date: 2008-04-10 Impact factor: 3.464