Literature DB >> 26390815

Structure and functional roles of Epac2 (Rapgef4).

Kenji Sugawara1, Tadao Shibasaki2, Harumi Takahashi2, Susumu Seino3.   

Abstract

Epac (exchange protein activated by cyclic-AMP) 2 is a direct target of 3'-5'-cyclic adenosine monophosphate (cAMP) and is involved in cAMP-mediated signal transduction through activation of the Ras-like small GTPase Rap. Crystallographic analyses revealed that activation of Epac2 by cAMP is accompanied by dynamic structural changes. Epac2 is expressed mainly in brain, neuroendocrine and endocrine tissues, and is involved in diverse cellular functions in the tissues. In this review, we summarize the structure and function of Epac2. We also discuss the physiological and pathophysiological roles of Epac2, and the possibility of Epac2 as a therapeutic target.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Epac2; Rap; cAMP

Mesh：

Substances：

Year:  2015        PMID： 26390815      PMCID： PMC6636354          DOI： 10.1016/j.gene.2015.09.029

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  18 in total

1.  Usefulness of circulating EPAC1 as biomarkers of therapeutic response to GLP-1 receptor agonists.

Authors:  Cristina Hernández; Fernando Gómez-Peralta; Rafael Simó; Olga Simó-Servat; Marta García-Ramírez; Cristina Abreu; Sara Gómez-Rodríguez
Journal:  Acta Diabetol       Date:  2022-08-04       Impact factor: 4.087

Review 2.  Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation-contraction coupling to mutations that cause inherited arrhythmia.

Authors:  Joshua A Keefe; Oliver M Moore; Kevin S Ho; Xander H T Wehrens
Journal:  Arch Toxicol       Date:  2022-10-10       Impact factor: 6.168

3.  A cell-based, quantitative and isoform-specific assay for exchange proteins directly activated by cAMP.

Authors:  Yingmin Zhu; Fang Mei; Pei Luo; Xiaodong Cheng
Journal:  Sci Rep       Date:  2017-07-24       Impact factor: 4.379

Review 4.  Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.

Authors:  Pingyuan Wang; Zhiqing Liu; Haiying Chen; Na Ye; Xiaodong Cheng; Jia Zhou
Journal:  Bioorg Med Chem Lett       Date:  2017-02-27       Impact factor: 2.823

5.  Adenosine A1 Receptor-Mediated Synaptic Depression in the Developing Hippocampal Area CA2.

Authors:  Douglas A Caruana; Serena M Dudek
Journal:  Front Synaptic Neurosci       Date:  2020-06-15

6.  The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex.

Authors:  Rebecca M Sena; Jeffery L Twiss; Amy S Gardiner; Michela Dell'Orco; David N Linsenbardt; Nora I Perrone-Bizzozero
Journal:  Molecules       Date:  2021-05-11       Impact factor: 4.927

Review 7.  Role of EPAC in cAMP-Mediated Actions in Adrenocortical Cells.

Authors:  Aurélia E Lewis; Reidun Aesoy; Marit Bakke
Journal:  Front Endocrinol (Lausanne)       Date:  2016-06-13       Impact factor: 5.555

8.  Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes.

Authors:  Jessica P Hekman; Jennifer L Johnson; Whitney Edwards; Anastasiya V Vladimirova; Rimma G Gulevich; Alexandra L Ford; Anastasiya V Kharlamova; Yury Herbeck; Gregory M Acland; Lori T Raetzman; Lyudmila N Trut; Anna V Kukekova
Journal:  G3 (Bethesda)       Date:  2018-03-02       Impact factor: 3.154

9.  Discovery of novel heart rate-associated loci using the Exome Chip.

Authors:  Marten E van den Berg; Helen R Warren; Claudia P Cabrera; Niek Verweij; Borbala Mifsud; Jeffrey Haessler; Nathan A Bihlmeyer; Yi-Ping Fu; Stefan Weiss; Henry J Lin; Niels Grarup; Ruifang Li-Gao; Giorgio Pistis; Nabi Shah; Jennifer A Brody; Martina Müller-Nurasyid; Honghuang Lin; Hao Mei; Albert V Smith; Leo-Pekka Lyytikäinen; Leanne M Hall; Jessica van Setten; Stella Trompet; Bram P Prins; Aaron Isaacs; Farid Radmanesh; Jonathan Marten; Aiman Entwistle; Jan A Kors; Claudia T Silva; Alvaro Alonso; Joshua C Bis; Rudolf de Boer; Hugoline G de Haan; Renée de Mutsert; George Dedoussis; Anna F Dominiczak; Alex S F Doney; Patrick T Ellinor; Ruben N Eppinga; Stephan B Felix; Xiuqing Guo; Yanick Hagemeijer; Torben Hansen; Tamara B Harris; Susan R Heckbert; Paul L Huang; Shih-Jen Hwang; Mika Kähönen; Jørgen K Kanters; Ivana Kolcic; Lenore J Launer; Man Li; Jie Yao; Allan Linneberg; Simin Liu; Peter W Macfarlane; Massimo Mangino; Andrew D Morris; Antonella Mulas; Alison D Murray; Christopher P Nelson; Marco Orrú; Sandosh Padmanabhan; Annette Peters; David J Porteous; Neil Poulter; Bruce M Psaty; Lihong Qi; Olli T Raitakari; Fernando Rivadeneira; Carolina Roselli; Igor Rudan; Naveed Sattar; Peter Sever; Moritz F Sinner; Elsayed Z Soliman; Timothy D Spector; Alice V Stanton; Kathleen E Stirrups; Kent D Taylor; Martin D Tobin; André Uitterlinden; Ilonca Vaartjes; Arno W Hoes; Peter van der Meer; Uwe Völker; Melanie Waldenberger; Zhijun Xie; Magdalena Zoledziewska; Andrew Tinker; Ozren Polasek; Jonathan Rosand; Yalda Jamshidi; Cornelia M van Duijn; Eleftheria Zeggini; J Wouter Jukema; Folkert W Asselbergs; Nilesh J Samani; Terho Lehtimäki; Vilmundur Gudnason; James Wilson; Steven A Lubitz; Stefan Kääb; Nona Sotoodehnia; Mark J Caulfield; Colin N A Palmer; Serena Sanna; Dennis O Mook-Kanamori; Panos Deloukas; Oluf Pedersen; Jerome I Rotter; Marcus Dörr; Chris J O'Donnell; Caroline Hayward; Dan E Arking; Charles Kooperberg; Pim van der Harst; Mark Eijgelsheim; Bruno H Stricker; Patricia B Munroe
Journal:  Hum Mol Genet       Date:  2017-06-15       Impact factor: 6.150

10.  Autophagy activity contributes to the impairment of social recognition in Epac2-/- mice.

Authors:  Ji-Hye Kwak; You-Kyung Lee; Mi-Hee Jun; Mootaek Roh; Hyunhyo Seo; Juhyun Lee; Kyungmin Lee; Jin-A Lee
Journal:  Mol Brain       Date:  2021-06-28       Impact factor: 4.041
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.