| Literature DB >> 26390813 |
Xiaolin He1, Yuan Chao2, Guangxian Zhou3, Yulin Chen4.
Abstract
To determine the relationship between fibroblast growth factor 5 (FGF5) and FGF5-short (FGF5s) in dermal papilla cells of cashmere goat primary and secondary hair follicles. We isolated dermal papilla cells from primary hair follicle (PHF) and secondary hair follicle (SHF) of cashmere goat, and found that the FGF5 receptor, fibroblast growth factor receptor 1 (FGFR1), was expressed in these two types of dermal papilla cells. Moreover, adenovirus-mediated overexpression of FGF5 could upregulate the mRNA expression of insulin-like growth factor-1 (IGF-1), versican and noggin that were important for follicle growth maintenance, whereas downregulate the expression of anagen chalone bone morphogenetic protein 4 (BMP4) in dermal papilla cells. However, these alterations were partly reversed by FGF5s overexpression. In conclusion, our results demonstrated that FGF5s acted as an inhibitor of FGF5 in the regulation of anagen-catagen transition of cashmere goat dermal papilla cells.Entities:
Keywords: Cashmere goat; Dermal papilla cell; FGF5; Primary hair follicle; Secondary hair follicle
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Year: 2015 PMID： 26390813 DOI： 10.1016/j.gene.2015.09.034
Source DB: PubMed Journal: Gene ISSN： 0378-1119 Impact factor: 3.688