AIMS: The aim of the present study was to compare vascular healing response between the first-generation sirolimus-eluting stent (SES) and the second-generation everolimus-eluting stent (EES) by using optical coherence tomography (OCT). METHODS AND RESULTS: The RESET was a prospective, multicentre, randomised, open-label trial comparing EES and SES. Of the 3,197 patients enrolled in the RESET, nine-month follow-up OCT after stent implantation was performed in 100 patients (48 EES-treated lesions in 44 patients and 62 SES-treated lesions in 56 patients), thus constituting the OCT substudy population. The percentage of uncovered struts per lesion (8±15% vs. 14±19%, p=0.031) and cross-sections with >30% uncovered struts per lesion (6±14% vs. 18±29%, p=0.009) was significantly lower in EES compared with SES. The frequency of DES-treated lesions with incomplete stent apposition (8 [17%] vs. 29 [47%], p<0.001) was significantly lower in EES compared with SES. Intra-stent thrombus was comparably observed between EES and SES (1 [2%] vs. 5 [8%], p=0.229). CONCLUSIONS: Compared with SES, EES was associated with a favourable vascular response at nine months after stent implantation.
RCT Entities:
AIMS: The aim of the present study was to compare vascular healing response between the first-generation sirolimus-eluting stent (SES) and the second-generation everolimus-eluting stent (EES) by using optical coherence tomography (OCT). METHODS AND RESULTS: The RESET was a prospective, multicentre, randomised, open-label trial comparing EES and SES. Of the 3,197 patients enrolled in the RESET, nine-month follow-up OCT after stent implantation was performed in 100 patients (48 EES-treated lesions in 44 patients and 62 SES-treated lesions in 56 patients), thus constituting the OCT substudy population. The percentage of uncovered struts per lesion (8±15% vs. 14±19%, p=0.031) and cross-sections with >30% uncovered struts per lesion (6±14% vs. 18±29%, p=0.009) was significantly lower in EES compared with SES. The frequency of DES-treated lesions with incomplete stent apposition (8 [17%] vs. 29 [47%], p<0.001) was significantly lower in EES compared with SES. Intra-stent thrombus was comparably observed between EES and SES (1 [2%] vs. 5 [8%], p=0.229). CONCLUSIONS: Compared with SES, EES was associated with a favourable vascular response at nine months after stent implantation.
Authors: Sho Torii; Hiroyuki Jinnouchi; Atsushi Sakamoto; Hiroyoshi Mori; Joohyung Park; Falone C Amoa; Mariem Sawan; Yu Sato; Anne Cornelissen; Salome H Kuntz; Matthew Kutyna; Ka Hyun Paek; Raquel Fernandez; Ryan Braumann; Eric K Mont; Dipti Surve; Maria E Romero; Frank D Kolodgie; Renu Virmani; Aloke V Finn Journal: Eur Heart J Date: 2020-02-01 Impact factor: 29.983
Authors: Stephen Hamshere; Alex Byrne; Tawfiq Choudhury; Sean M Gallagher; Krishnaraj S Rathod; Julia Lungley; Charles J Knight; Akhil Kapur; Daniel A Jones; Anthony Mathur Journal: Open Heart Date: 2018-04-05
Authors: Robert J Gil; Jacek Bil; Jacek Legutko; Tomasz Pawłowski; Katarzyna E Gil; Dariusz Dudek; Ricardo A Costa Journal: Int J Cardiovasc Imaging Date: 2017-09-30 Impact factor: 2.357