| Literature DB >> 26390066 |
Roongroj Bhidayasiri1, Nobutaka Hattori2, Beomseok Jeon3, Rou-Shayn Chen4, Moon Keen Lee5, Jawad A Bajwa6, Vincent C T Mok7, Baorong Zhang8, Thamrin Syamsudin9, Louis Chew Seng Tan10, Roland Dominic G Jamora11,12, Apichart Pisarnpong13, Werner Poewe14.
Abstract
Most Parkinson's disease patients will receive levodopa therapy, and of these, the majority will develop some levodopa-induced complications. For many patients, the first complication to develop is the decline in the duration of therapeutic benefit of each levodopa dose, a phenomenon commonly termed 'wearing-off'. There is already extensive literature documenting the epidemiology and management of wearing-off in Parkinson's disease patients of western descent. However, data derived from these studies might not always apply to patients of Asian descent due to genetic variations, differences in co-morbidities or non-availability of certain drugs. This review summarizes the current literature regarding the epidemiology of wearing-off in Asian (including Arab) patients and discusses the management issues in the context of drug availability in Asia.Entities:
Keywords: Arab; Asia; Parkinson’s disease; fluctuations; non-motor; screening tools; wearing-off
Mesh：
Substances：
Year: 2015 PMID： 26390066 DOI： 10.1586/14737175.2015.1088783
Source DB: PubMed Journal: Expert Rev Neurother ISSN： 1473-7175 Impact factor: 4.618