Asnat Walfisch1, Roy Kessous2, Ehud Davidson3, Ruslan Sergienko4, Eyal Sheiner2. 1. a Department of Obstetrics and Gynecology , Hillel-Yaffe Medical Center affiliated with The Bruce and Ruth Rappaport Faculty of Medicine, Technion, Israel Institute of Technology , Hadera , Israel . 2. b Department of Obstetrics and Gynecology, Faculty of Health Sciences , Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva , Israel . 3. c Soroka University Medical Center, Clalit Health Services (Southern District), Faculty of Health Sciences, Ben-Gurion University of the Negev , Beer-Sheva , Israel , and. 4. d Department of Public Health , Ben-Gurion University of the Negev , Beer-Sheva , Israel.
Abstract
OBJECTIVE: To investigate an association between pre-eclampsia and future genital tract and breast malignancies. METHODS: The incidence of genital tract and breast malignancies was compared in a cohort of women with and without a history of pre-eclampsia. Cumulative incidence was assessed using a Kaplan-Meier survival curve. RESULTS: During the study period, 103 180 deliveries met the inclusion criteria; 8.1% occurred in patients with pre-eclampsia. Patients with pre-eclampsia did not have a significantly different risk of genital tract or breast malignancies. The results remained insignificant in a sub-analysis based on malignancy type, pre-eclampsia severity and number of episodes per patient. No difference in cumulative incidence was demonstrated. CONCLUSION: Pre-eclampsia does not appear to influence the risk of future genital tract or breast malignancies.
OBJECTIVE: To investigate an association between pre-eclampsia and future genital tract and breast malignancies. METHODS: The incidence of genital tract and breast malignancies was compared in a cohort of women with and without a history of pre-eclampsia. Cumulative incidence was assessed using a Kaplan-Meier survival curve. RESULTS: During the study period, 103 180 deliveries met the inclusion criteria; 8.1% occurred in patients with pre-eclampsia. Patients with pre-eclampsia did not have a significantly different risk of genital tract or breast malignancies. The results remained insignificant in a sub-analysis based on malignancy type, pre-eclampsia severity and number of episodes per patient. No difference in cumulative incidence was demonstrated. CONCLUSION: Pre-eclampsia does not appear to influence the risk of future genital tract or breast malignancies.
Authors: Mandy Goldberg; Mary V Díaz-Santana; Katie M O'Brien; Shanshan Zhao; Clarice R Weinberg; Dale P Sandler Journal: Epidemiology Date: 2022-05-30 Impact factor: 4.860
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