Yoo Jin Lee1, Dong Wook Kim1, Young Mi Park1, Ha Kyoung Park2, Soo Jin Jung3, Do Hun Kim4, Seok Mo Lee5, Minkyung Oh6. 1. Department of Radiology, Busan Paik Hospital, Inje University College of Medicine, 614-735, Busan, South Korea. 2. Department of General Surgery, Busan Paik Hospital, Inje University College of Medicine, 614-735, Busan, South Korea. 3. Department of Pathology, Busan Paik Hospital, Inje University College of Medicine, 614-735, Busan, South Korea. 4. Department of Otorhinolaryngology-Head and Neck Surgery, Busan Paik Hospital, Inje University College of Medicine, 614-735, Busan, South Korea. 5. Department of Nuclear Medicine, Busan Paik Hospital, Inje University College of Medicine, 614-735, Busan, South Korea. 6. Department of Pharmacology and Clinical Trial Center, Busan Paik Hospital, Inje University College of Medicine, 614-735, Busan, South Korea.
Abstract
BACKGROUND: This study aimed to assess solid thyroid nodule (STN) cases with discordant sonographic and cytological diagnoses and to compare the diagnostic indices of these modalities. METHODS: From January 2013 to December 2013, a single radiologist performed consecutive thyroid ultrasonography (US) and US-guided fine-needle aspiration (US-FNA) to diagnose 347 STNs in 347 patients. Each STN was classified into 1 of 5 categories according to the US diagnosis before US-FNA: "benign," "probably benign," "indeterminate," "suspicious for malignancy," or "malignant." We assessed cases where the sonographic and cytological STN diagnoses were discordant, using the final diagnosis as the reference standard. RESULTS: Of the 347 STNs, 279 (80.4%) had a final diagnosis confirmed. The "benign," "probably benign," and "malignant" US categories showed high concordance with the cytological diagnoses, whereas the "suspicious for malignancy" US category revealed only a 62.2% concordance rate. The prevalence of indeterminate cytology was higher in the "indeterminate" and "suspicious for malignancy" US categories than other US categories. STNs with indeterminate cytology showed a higher malignancy rate in the malignant US categories. When STNs classified into indeterminate categories from the sonographic (n = 49) and cytological (n = 18) diagnoses were excluded, the sensitivity, specificity, and accuracy of the sonographic and cytological diagnoses were 95.5 and 98.8%, 92.1 and 100%, and 93.0 and 99.6%, respectively. CONCLUSION: The "suspicious for malignancy" US category showed higher discordance with cytological diagnoses than other US categories, and the diagnostic value of US was lower than that of cytology.
BACKGROUND: This study aimed to assess solid thyroid nodule (STN) cases with discordant sonographic and cytological diagnoses and to compare the diagnostic indices of these modalities. METHODS: From January 2013 to December 2013, a single radiologist performed consecutive thyroid ultrasonography (US) and US-guided fine-needle aspiration (US-FNA) to diagnose 347 STNs in 347 patients. Each STN was classified into 1 of 5 categories according to the US diagnosis before US-FNA: "benign," "probably benign," "indeterminate," "suspicious for malignancy," or "malignant." We assessed cases where the sonographic and cytological STN diagnoses were discordant, using the final diagnosis as the reference standard. RESULTS: Of the 347 STNs, 279 (80.4%) had a final diagnosis confirmed. The "benign," "probably benign," and "malignant" US categories showed high concordance with the cytological diagnoses, whereas the "suspicious for malignancy" US category revealed only a 62.2% concordance rate. The prevalence of indeterminate cytology was higher in the "indeterminate" and "suspicious for malignancy" US categories than other US categories. STNs with indeterminate cytology showed a higher malignancy rate in the malignant US categories. When STNs classified into indeterminate categories from the sonographic (n = 49) and cytological (n = 18) diagnoses were excluded, the sensitivity, specificity, and accuracy of the sonographic and cytological diagnoses were 95.5 and 98.8%, 92.1 and 100%, and 93.0 and 99.6%, respectively. CONCLUSION: The "suspicious for malignancy" US category showed higher discordance with cytological diagnoses than other US categories, and the diagnostic value of US was lower than that of cytology.
Authors: Da Som Kim; Dong Wook Kim; Young Jin Heo; Jin Wook Baek; Yoo Jin Lee; Hye Jung Choo; Young Mi Park; Ha Kyoung Park; Tae Kwun Ha; Do Hun Kim; Soo Jin Jung; Ji Sun Park; Ki Jung Ahn; Hye Jin Baek; Taewoo Kang Journal: PLoS One Date: 2018-08-17 Impact factor: 3.240
Authors: Yoo Jin Lee; Dong Wook Kim; Gi Won Shin; Young Jin Heo; Jin Young Park; Jin Wook Baek; Hye Jung Choo; Young Jun Cho; Ha Kyoung Park; Tae Kwun Ha; Do Hun Kim; Soo Jin Jung; Ji Sun Park; Sung Ho Moon; Ki Jung Ahn Journal: Front Endocrinol (Lausanne) Date: 2019-11-12 Impact factor: 5.555
Authors: Taewoo Kang; Dong Wook Kim; Gi Won Shin; Jin Young Park; Yoo Jin Lee; Hye Jung Choo; Young Jun Cho; Soo Jin Jung; Ha Kyoung Park; Tae Kwun Ha; Do Hun Kim; Ji Sun Park; Sung Ho Moon; Ki Jung Ahn; Hye Jin Baek Journal: Med Sci Monit Date: 2019-09-15