Literature DB >> 26389671

Transplant tolerance: a new role for IL-34.

James I Kim, Laurence A Turka.   

Abstract

Immune-suppressive cell populations, including Tregs and suppressor monocytes, have been implicated in long-term survival of allografts in both human transplant recipients and animal models. The factors that drive differentiation and function of these cell populations are not completely understood. In this issue, Bézie and colleagues identify IL-34 as an important mediator of allograft tolerance in a rat model of heart transplantation. Their data support a model in which IL-34 production by Tregs promotes a population of suppressive macrophages that in turn promote Treg differentiation. The results of this study support further exploration of the immunosuppressive properties of IL-34.

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Year:  2015        PMID： 26389671      PMCID： PMC4607117          DOI： 10.1172/JCI84010

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  20 in total

1.  Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.

Authors:  Suwen Wei; Sayan Nandi; Violeta Chitu; Yee-Guide Yeung; Wenfeng Yu; Minmei Huang; Lewis T Williams; Haishan Lin; E Richard Stanley
Journal:  J Leukoc Biol       Date:  2010-05-26       Impact factor: 4.962

Review 2.  How do CD4+CD25+ regulatory T cells control autoimmunity?

Authors:  Jeffrey A Bluestone; Qizhi Tang
Journal:  Curr Opin Immunol       Date:  2005-10-04       Impact factor: 7.486

3.  CD40Ig treatment results in allograft acceptance mediated by CD8CD45RC T cells, IFN-gamma, and indoleamine 2,3-dioxygenase.

Authors:  Carole Guillonneau; Marcelo Hill; François-Xavier Hubert; Elise Chiffoleau; Caroline Hervé; Xian-Liang Li; Michèle Heslan; Claire Usal; Laurent Tesson; Séverine Ménoret; Abdelhadi Saoudi; Brigitte Le Mauff; Régis Josien; Maria Cristina Cuturi; Ignacio Anegon
Journal:  J Clin Invest       Date:  2007-04       Impact factor: 14.808

4.  Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.

Authors:  Bo Huang; Ping-Ying Pan; Qingsheng Li; Alice I Sato; David E Levy; Jonathan Bromberg; Celia M Divino; Shu-Hsia Chen
Journal:  Cancer Res       Date:  2006-01-15       Impact factor: 12.701

5.  Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells.

Authors:  Natalie A Carter; Rita Vasconcellos; Elizabeth C Rosser; Calogero Tulone; Alba Muñoz-Suano; Masahito Kamanaka; Michael R Ehrenstein; Richard A Flavell; Claudia Mauri
Journal:  J Immunol       Date:  2011-04-04       Impact factor: 5.422

6.  Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice.

Authors:  Mercedes Rodriguez Garcia; Levi Ledgerwood; Yu Yang; Jiangnan Xu; Girdhari Lal; Bryna Burrell; Ge Ma; Daigo Hashimoto; Yansui Li; Peter Boros; Marcos Grisotto; Nico van Rooijen; Rafael Matesanz; Frank Tacke; Florent Ginhoux; Yaozhong Ding; Shu-Hsia Chen; Gwendalyn Randolph; Miriam Merad; Jonathan S Bromberg; Jordi C Ochando
Journal:  J Clin Invest       Date:  2010-06-14       Impact factor: 14.808

7.  IL-34 is a Treg-specific cytokine and mediates transplant tolerance.

Authors:  Séverine Bézie; Elodie Picarda; Jason Ossart; Laurent Tesson; Claire Usal; Karine Renaudin; Ignacio Anegon; Carole Guillonneau
Journal:  J Clin Invest       Date:  2015-09-21       Impact factor: 14.808

8.  Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.

Authors:  Haishan Lin; Ernestine Lee; Kevin Hestir; Cindy Leo; Minmei Huang; Elizabeth Bosch; Robert Halenbeck; Ge Wu; Aileen Zhou; Dirk Behrens; Diane Hollenbaugh; Thomas Linnemann; Minmin Qin; Justin Wong; Keting Chu; Stephen K Doberstein; Lewis T Williams
Journal:  Science       Date:  2008-05-09       Impact factor: 47.728

9.  Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.

Authors:  Nigel D L Savage; Tjitske de Boer; Kimberley V Walburg; Simone A Joosten; Krista van Meijgaarden; Annemiek Geluk; Tom H M Ottenhoff
Journal:  J Immunol       Date:  2008-08-01       Impact factor: 5.422

Review 10.  Mother's little helpers: mechanisms of maternal-fetal tolerance.

Authors:  John Trowsdale; Alexander G Betz
Journal:  Nat Immunol       Date:  2006-03       Impact factor: 25.606
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  2 in total

Review 1.  Immunoregulatory properties of the cytokine IL-34.

Authors:  Carole Guillonneau; Séverine Bézie; Ignacio Anegon
Journal:  Cell Mol Life Sci       Date:  2017-03-03       Impact factor: 9.261

2.  Ex Vivo Expanded Human Non-Cytotoxic CD8+CD45RClow/- Tregs Efficiently Delay Skin Graft Rejection and GVHD in Humanized Mice.

Authors:  Séverine Bézie; Dimitri Meistermann; Laetitia Boucault; Stéphanie Kilens; Johanna Zoppi; Elodie Autrusseau; Audrey Donnart; Véronique Nerrière-Daguin; Frédérique Bellier-Waast; Eric Charpentier; Franck Duteille; Laurent David; Ignacio Anegon; Carole Guillonneau
Journal:  Front Immunol       Date:  2018-01-31       Impact factor: 7.561
  2 in total

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