| Literature DB >> 26388561 |
N V Andreeva1,2, A P Bonartsev3,4, I I Zharkova2, T K Makhina5, V L Myshkina5, E P Kharitonova6, V V Voinova2,5, G A Bonartseva6, K V Shaitan2, A V Belyavskii1.
Abstract
We studied the possibility of long-term culturing of mouse mesenchymal stem cells on a porous scaffold made of biocompatible polymer poly-3-hydroxybutyrate. The cells remained viable for at least 2 months and passed more than 65 population doublings in culture. Culturing on the scaffold did not change surface phenotype of cells. 3D poly-3-hydroxybutyrate scaffolds are appropriate substrate for long-term culturing of mesenchymal stem cells.Entities:
Keywords: mesenchymal stem cells; poly-3-hydroxybutyrate; polymer scaffold
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Year: 2015 PMID： 26388561 DOI： 10.1007/s10517-015-3015-5
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804