| Literature DB >> 26388050 |
Tatsuo Kanda1, Reina Sasaki2, Shingo Nakamoto3, Yuki Haga2, Masato Nakamura2, Hiroshi Shirasawa4, Hiroaki Okamoto5, Osamu Yokosuka2.
Abstract
Epigenetics plays a role in the regulation of gene expression. Epigenetic changes control gene expression at the transcriptional level. Our previous study suggested that the La protein, which is mainly localized in the nucleus, was associated with hepatitis A virus (HAV) internal ribosomal entry site (IRES)-mediated translation and HAV replication. The aim of this study was to investigate whether epigenetic compounds have effects on HAV IRES-mediated translation and HAV replication. Sirtinol, a sirtuin inhibitor, inhibited HAV IRES-mediated translation in COS7-HAV-IRES cells. Treatment with 10 μM sirtinol resulted in a significant reduction in the intracellular RNA levels of HAV HA11-1299 genotype IIIA in Huh7 cells. Epigenetic treatment with a sirtuin inhibitor may represent a new treatment option for HAV infection. In conclusion, epigenetic control was involved in HAV IRES-dependent translation and HAV replication. Special attention should also be paid to underlying viral diseases in the clinical use of epigenetic treatments for malignancies.Entities:
Keywords: HAV; IRES; JNJ-7706621; Sirtinol
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Year: 2015 PMID： 26388050 DOI： 10.1016/j.bbrc.2015.09.083
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575