Qingwen Zhu1, Lingli Zhang1, Xiaobo Chen1, Jun Zhou1, Jiangyue Liu1, Jianhua Chen2. 1. Department of Prenatal Diagnosis Center, Nantong Maternity and Child Health Hospital, Nantong, Jiangsu, 226006, People's Republic of China. 2. President's Office, Nantong Maternity and Child Health Hospital, No. 399, Century Avenue, Nantong, Jiangsu, 226006, People's Republic of China. jianhuachen888@163.com.
Abstract
BACKGROUND: Epidemiological studies evaluating the association between zinc level and the risk of preeclampsia have produced inconsistent results. We therefore conducted a meta-analysis to summarize the evidence for them. METHODS: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to April 2015. Standardized mean difference (SMD) was performed to combine the results. Random-effect model was used. Publication bias was estimated using Egger's regression asymmetry test. RESULTS: Thirteen articles (11 case-control studies and 2 cross-sectional studies) involving 445 preeclampsia cases and 568 healthy controls were included in this meta-analysis. Our pooled results suggested that preeclampsia patients had a lower zinc level as compared with healthy, pregnant controls (summary SMD = -0.61, 95 % CI = -0.74, -0.48, I (2) = 88.5 %). The association was also significant in Asia (SMD = -0.73, 95 % CI = -0.88, -0.58), but not in Europe. No publication biases were found. CONCLUSIONS: Our analysis indicated that zinc level in preeclampsia patients was significantly lower than that of healthy, pregnant women, especially among the Asian population.
BACKGROUND: Epidemiological studies evaluating the association between zinc level and the risk of preeclampsia have produced inconsistent results. We therefore conducted a meta-analysis to summarize the evidence for them. METHODS: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to April 2015. Standardized mean difference (SMD) was performed to combine the results. Random-effect model was used. Publication bias was estimated using Egger's regression asymmetry test. RESULTS: Thirteen articles (11 case-control studies and 2 cross-sectional studies) involving 445 preeclampsia cases and 568 healthy controls were included in this meta-analysis. Our pooled results suggested that preeclampsia patients had a lower zinc level as compared with healthy, pregnant controls (summary SMD = -0.61, 95 % CI = -0.74, -0.48, I (2) = 88.5 %). The association was also significant in Asia (SMD = -0.73, 95 % CI = -0.88, -0.58), but not in Europe. No publication biases were found. CONCLUSIONS: Our analysis indicated that zinc level in preeclampsia patients was significantly lower than that of healthy, pregnant women, especially among the Asian population.
Authors: Paige A Bommarito; Stephani S Kim; John D Meeker; Rebecca C Fry; David E Cantonwine; Thomas F McElrath; Kelly K Ferguson Journal: Environ Health Date: 2019-07-12 Impact factor: 5.984
Authors: Mai-Lei Woo Kinshella; Shazmeen Omar; Kerri Scherbinsky; Marianne Vidler; Laura A Magee; Peter von Dadelszen; Sophie E Moore; Rajavel Elango Journal: Reprod Health Date: 2022-09-05 Impact factor: 3.355