BACKGROUND: The purpose of this study was to evaluate the efficacy of buspirone, a partial 5-HT1A agonist, for treatment of cannabis dependence. METHODS:One hundred seventy-five cannabis-dependent adults were randomized to receive either up to 60mg/day of buspirone (n=88) or placebo (n=87) for 12 weeks combined with a brief motivational enhancement therapy intervention and contingency management to encourage study retention. Cannabis use outcomes were assessed via weekly urine cannabinoid tests. RESULTS: Participants in both groups reported reduced cannabis craving over the course of the study; however, buspirone provided no advantage over placebo in reducing cannabis use. Significant gender by treatment interactions were observed, with women randomized to buspirone having fewer negative urine cannabinoid tests than women randomized to placebo (p=0.007), and men randomized to buspirone having significantly lower creatinine adjusted cannabinoid levels as compared to those randomized to placebo (p=0.023). An evaluation of serotonin allelic variations did not find an association with buspirone treatment response. CONCLUSIONS:Buspirone was not more efficacious than placebo in reducing cannabis use. Important gender differences were noted, with women having worse cannabis use outcomes with buspirone treatment. Considerations for future medication trials in this challenging population are discussed.
RCT Entities:
BACKGROUND: The purpose of this study was to evaluate the efficacy of buspirone, a partial 5-HT1A agonist, for treatment of cannabis dependence. METHODS: One hundred seventy-five cannabis-dependent adults were randomized to receive either up to 60mg/day of buspirone (n=88) or placebo (n=87) for 12 weeks combined with a brief motivational enhancement therapy intervention and contingency management to encourage study retention. Cannabis use outcomes were assessed via weekly urine cannabinoid tests. RESULTS:Participants in both groups reported reduced cannabis craving over the course of the study; however, buspirone provided no advantage over placebo in reducing cannabis use. Significant gender by treatment interactions were observed, with women randomized to buspirone having fewer negative urine cannabinoid tests than women randomized to placebo (p=0.007), and men randomized to buspirone having significantly lower creatinine adjusted cannabinoid levels as compared to those randomized to placebo (p=0.023). An evaluation of serotonin allelic variations did not find an association with buspirone treatment response. CONCLUSIONS:Buspirone was not more efficacious than placebo in reducing cannabis use. Important gender differences were noted, with women having worse cannabis use outcomes with buspirone treatment. Considerations for future medication trials in this challenging population are discussed.
Authors: Frances R Levin; John J Mariani; Daniel J Brooks; Martina Pavlicova; Wendy Cheng; Edward V Nunes Journal: Drug Alcohol Depend Date: 2011-02-18 Impact factor: 4.492
Authors: Kevin M Gray; Matthew J Carpenter; Nathaniel L Baker; Karen J Hartwell; A Lee Lewis; D Walter Hiott; Deborah Deas; Himanshu P Upadhyaya Journal: J Subst Abuse Treat Date: 2010-10-08
Authors: Aimee L McRae-Clark; Rickey E Carter; Therese K Killeen; Matthew J Carpenter; Kathleen G White; Kathleen T Brady Journal: Am J Addict Date: 2010-09-21
Authors: Aimee L McRae-Clark; Rickey E Carter; Therese K Killeen; Matthew J Carpenter; Amy E Wahlquist; Stacey A Simpson; Kathleen T Brady Journal: Drug Alcohol Depend Date: 2009-08-21 Impact factor: 4.492
Authors: Sylvie Lemonde; Gustavo Turecki; David Bakish; Lisheng Du; Pavel D Hrdina; Christopher D Bown; Adolfo Sequeira; Neena Kushwaha; Stephen J Morris; Ajoy Basak; Xiao-Ming Ou; Paul R Albert Journal: J Neurosci Date: 2003-09-24 Impact factor: 6.167
Authors: Brian J Sherman; Aimee L McRae-Clark; Nathaniel L Baker; Susan C Sonne; Therese K Killeen; Kasie Cloud; Kevin M Gray Journal: Am J Addict Date: 2017-02-02
Authors: Dustin C Lee; Nicolas J Schlienz; Erica N Peters; Robert H Dworkin; Dennis C Turk; Eric C Strain; Ryan Vandrey Journal: Drug Alcohol Depend Date: 2018-11-15 Impact factor: 4.492
Authors: Aimee L McRae-Clark; Nathaniel L Baker; Kevin M Gray; Therese Killeen; Karen J Hartwell; Susan J Simonian Journal: Am J Addict Date: 2015-12-20