Jesús Herranz González-Botas1, Patricia Varela Vázquez2, Carlos Vázquez Barro2. 1. Servicio de Otorrinolaringología, Complexo Hospitalario Universitario A Coruña, A Coruña, España. Electronic address: jesus.herranz.gonzalez.botas@sergas.es. 2. Servicio de Otorrinolaringología, Complexo Hospitalario Universitario A Coruña, A Coruña, España.
Abstract
INTRODUCTION AND OBJECTIVES: Head and neck cancer patients have a higher risk of second primary tumours than the general population. The most frequent locations are head and neck, lung and oesophagus, decreasing long-term survival. The aim of this work was to analyse the incidence, location according to index tumour and stage, chronology, patient age, and survival after diagnosis. METHOD: Retrospective study on 579 patients with head and neck squamous cell carcinoma, treated with curative intent, with a minimum 24-month follow-up. Early stages (I/II) were 42.4%, and 57.6% were stages III and IV. RESULTS: Second primary tumour incidence was 15% (87/579), with 9.2% (8/97) developing a third tumour. The most frequent locations of the second tumours were head and neck, 37.9% (33/87); lung, 36.8% (32/87); oesophagus, 5.7% (5/87); and colon, 5.7% (5/87). Five- and 10-year survival in patients without a second tumour was 65.1% and 52.7% respectively, versus 58.7% and 40.2% in those who developed one. CONCLUSIONS: The incidence of second primary tumours increased in the last decade, having a negative effect on survival. Since no specific early diagnosis tool is available, alcohol and tobacco avoidance along with scheduled follow-up are suggested procedures to reduce its incidence.
INTRODUCTION AND OBJECTIVES: Head and neck cancerpatients have a higher risk of second primary tumours than the general population. The most frequent locations are head and neck, lung and oesophagus, decreasing long-term survival. The aim of this work was to analyse the incidence, location according to index tumour and stage, chronology, patient age, and survival after diagnosis. METHOD: Retrospective study on 579 patients with head and neck squamous cell carcinoma, treated with curative intent, with a minimum 24-month follow-up. Early stages (I/II) were 42.4%, and 57.6% were stages III and IV. RESULTS: Second primary tumour incidence was 15% (87/579), with 9.2% (8/97) developing a third tumour. The most frequent locations of the second tumours were head and neck, 37.9% (33/87); lung, 36.8% (32/87); oesophagus, 5.7% (5/87); and colon, 5.7% (5/87). Five- and 10-year survival in patients without a second tumour was 65.1% and 52.7% respectively, versus 58.7% and 40.2% in those who developed one. CONCLUSIONS: The incidence of second primary tumours increased in the last decade, having a negative effect on survival. Since no specific early diagnosis tool is available, alcohol and tobacco avoidance along with scheduled follow-up are suggested procedures to reduce its incidence.
Authors: G Cadoni; L Giraldi; L Petrelli; M Pandolfini; M Giuliani; G Paludetti; R Pastorino; E Leoncini; D Arzani; G Almadori; S Boccia Journal: Acta Otorhinolaryngol Ital Date: 2017-12 Impact factor: 2.124
Authors: Oisín Bugter; Steffi E M van de Ven; Jose A Hardillo; Marco J Bruno; Arjun D Koch; Robert J Baatenburg de Jong Journal: Head Neck Date: 2018-12-28 Impact factor: 3.147