Literature DB >> 26386389

Modulation of epithelial-to-mesenchymal cancerous transition by natural products.

Lei Zhang1, Xue Wang1, Maode Lai2.   

Abstract

Metastasis is mainly responsible for poor prognosis of cancer, and epithelial-to-mesenchymal transition (EMT) is a significant process often activated during cancer invasion and metastasis. Therefore EMT could be an effective target of chemotherapy to inhibit cancer metastasis and improve prognosis. Considering that many chemotherapeutics are plant-based, we reviewed recent reports about natural products extracted from plants and cancer EMT prevention.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Carcinoma; Chemotherapy; Epithelial-to-mesenchymal transition; Metastasis; Natural products; Pathway signaling

Mesh：

Substances：

Year:  2015        PMID： 26386389     DOI： 10.1016/j.fitote.2015.09.013

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  6 in total

1.  ZNF143 enhances metastasis of gastric cancer by promoting the process of EMT through PI3K/AKT signaling pathway.

Authors:  Song Wei; Linjun Wang; Lei Zhang; Bowen Li; Zheng Li; Qun Zhang; Jiwei Wang; Liang Chen; Guangli Sun; Qing Li; Hao Xu; Diancai Zhang; Zekuan Xu
Journal:  Tumour Biol       Date:  2016-07-23

2.  GPR56 promotes proliferation of colorectal cancer cells and enhances metastasis via epithelial‑mesenchymal transition through PI3K/AKT signaling activation.

Authors:  Bing Ji; Yifei Feng; Ye Sun; Dongjian Ji; Wenwei Qian; Zhiyuan Zhang; Qingyuan Wang; Yue Zhang; Chuan Zhang; Yueming Sun
Journal:  Oncol Rep       Date:  2018-07-20       Impact factor: 3.906

3.  PMEPA1 induces EMT via a non-canonical TGF-β signalling in colorectal cancer.

Authors:  Lei Zhang; Xue Wang; Chong Lai; Honghe Zhang; Maode Lai
Journal:  J Cell Mol Med       Date:  2019-03-19       Impact factor: 5.310

4.  Periostin, a signal transduction intermediate in TGF-β-induced EMT in U-87MG human glioblastoma cells, and its inhibition by anthocyanidins.

Authors:  Amira Ouanouki; Sylvie Lamy; Borhane Annabi
Journal:  Oncotarget       Date:  2018-04-24

5.  Anthocyanidins Inhibit Growth and Chemosensitize Triple-Negative Breast Cancer via the NF-κB Signaling Pathway.

Authors:  Farrukh Aqil; Radha Munagala; Ashish K Agrawal; Jeyaprakash Jeyabalan; Neha Tyagi; Shesh N Rai; Ramesh C Gupta
Journal:  Cancers (Basel)       Date:  2021-12-13       Impact factor: 6.639

6.  Grape Seed Proanthocyanidins Inhibit Migration and Invasion of Bladder Cancer Cells by Reversing EMT through Suppression of TGF-β Signaling Pathway.

Authors:  Ninggang Yang; Jing Gao; Ruizhen Hou; Xiaoli Xu; Ningqiang Yang; Shuangsheng Huang
Journal:  Oxid Med Cell Longev       Date:  2021-07-27       Impact factor: 6.543
  6 in total

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