Lu Tang1, Jing Xiang2, Shuyang Huang1, Ailiang Miao1, Huaiting Ge1, Hongxing Liu1, Di Wu1, Qingshan Guan1, Ting Wu3, Qiqi Chen3, Lu Yang3, Xiaopeng Lu4, Zheng Hu4, Xiaoshan Wang5. 1. Department of Neurology, Nanjing Medical University, Affiliated Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China. 2. MEG Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45220, USA. 3. MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China. 4. Department of Neurology, Nanjing Children's Hospital, Nanjing, Jiangsu 210029, China. 5. Department of Neurology, Nanjing Medical University, Affiliated Nanjing Brain Hospital, Nanjing, Jiangsu 210029, China. Electronic address: lidou2005@126.com.
Abstract
OBJECTIVE: This study quantified the clinical correlation of interictal and ictal neuromagnetic activities from low- to very-high-frequency ranges in childhood absence epilepsy (CAE). METHODS: Twelve patients with clinically diagnosed drug-naïve CAE were studied using a 275-channel whole-head magnetoencephalography (MEG) system. MEG data were digitized at 6000 Hz and analyzed at both sensor and source levels with multi-frequency analyses. RESULTS: Neuromagnetic changes from interictal to ictal periods predominantly occurred in medial prefrontal cortex and parieto-occipito-temporal junction in absence seizures. The changes were statistically significant in low-frequency bands only (<30 Hz, p<0.0001). There was a significant correlation between the source strength of ictal high-frequency oscillations (HFOs) in 200-1000 Hz and the number of daily seizures (r=0.734, p<0.01). CONCLUSIONS: CAE has focal neuromagnetic sources. The transition from interictal to ictal periods is associated with the elevation of low-frequency brain activities. The strength of HFOs reflects the severity of absence seizures. SIGNIFICANCE: Low- and high-frequency MEG signals reveal distinct brain activities in CAE. HFOs is a new biomarker for the study of absence seizures.
OBJECTIVE: This study quantified the clinical correlation of interictal and ictal neuromagnetic activities from low- to very-high-frequency ranges in childhood absence epilepsy (CAE). METHODS: Twelve patients with clinically diagnosed drug-naïve CAE were studied using a 275-channel whole-head magnetoencephalography (MEG) system. MEG data were digitized at 6000 Hz and analyzed at both sensor and source levels with multi-frequency analyses. RESULTS: Neuromagnetic changes from interictal to ictal periods predominantly occurred in medial prefrontal cortex and parieto-occipito-temporal junction in absence seizures. The changes were statistically significant in low-frequency bands only (<30 Hz, p<0.0001). There was a significant correlation between the source strength of ictal high-frequency oscillations (HFOs) in 200-1000 Hz and the number of daily seizures (r=0.734, p<0.01). CONCLUSIONS: CAE has focal neuromagnetic sources. The transition from interictal to ictal periods is associated with the elevation of low-frequency brain activities. The strength of HFOs reflects the severity of absence seizures. SIGNIFICANCE: Low- and high-frequency MEG signals reveal distinct brain activities in CAE. HFOs is a new biomarker for the study of absence seizures.
Authors: Birgit Frauscher; Fabrice Bartolomei; Katsuhiro Kobayashi; Jan Cimbalnik; Maryse A van 't Klooster; Stefan Rampp; Hiroshi Otsubo; Yvonne Höller; Joyce Y Wu; Eishi Asano; Jerome Engel; Philippe Kahane; Julia Jacobs; Jean Gotman Journal: Epilepsia Date: 2017-06-30 Impact factor: 5.864
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