| Literature DB >> 26384594 |
David Taïeb1, Philippe Garrigue2, Manuel Bardiès3, Ahmad Esmaeel Abdullah4, Karel Pacak5.
Abstract
Neuroendocrine tumors (NETs) are associated with variable prognosis, with grade 1 and 2 NETs having more favorable outcomes than grade 3. Patients with gastroenteropancreatic (GEP)-NET need individualized interdisciplinary evaluations and treatment. New treatment options have become available with significant improvements in progression-free survival. Peptide receptor radionuclide therapy (PRRT) using (90)Y or (177)Lu-labeled somatostatin analogues (SSTa) has also shown promise in the treatment of advanced progressive NETs. (68)Ga-1,4,7,10-tetraazacyclodecane-1,4,7,10-tetraacetic acid (DOTA)-SSTa can be used as companion imaging agents to assist in radionuclide therapy selection. (68)Ga-DOTA-SSTa PET/computed tomography might also provide information for prognosis, tumor response assessment to PRRT, and internal dosimetry.Entities:
Keywords: Gallium radioisotopes; Gastroenteropancreatic; Neuroendocrine; PET; Somatostatin
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Year: 2015 PMID: 26384594 PMCID: PMC4617555 DOI: 10.1016/j.cpet.2015.06.001
Source DB: PubMed Journal: PET Clin ISSN: 1556-8598