Literature DB >> 26384575

Genetic analysis of the RELN gene: Gender specific association with Alzheimer's disease.

Ágnes Fehér1, Anna Juhász2, Magdolna Pákáski2, János Kálmán2, Zoltán Janka2.   

Abstract

Association between genetic variants of the reelin (RELN) gene and the risk for developing Alzheimer's disease (AD) was examined in a sample of 432 patients and 308 controls. Single marker and haplotype analyses revealed that the strongly linked rs528528 and rs607755 polymorphisms are associated with AD risk in a gender specific manner. Among men, but not in women the rs528528 T/T and rs607755 A/A genotypes were significantly associated with the susceptibility to AD.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Alzheimer's disease; Association study; Reelin (RELN)

Mesh：

Substances：

Year:  2015        PMID： 26384575     DOI： 10.1016/j.psychres.2015.09.021

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  9 in total

Review 1.  Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders.

Authors:  Lucio G Costa; Toby B Cole; Khoi Dao; Yu-Chi Chang; Jacki Coburn; Jacqueline M Garrick
Journal:  Pharmacol Ther       Date:  2020-03-09       Impact factor: 12.310

2.  Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease.

Authors:  Giampiero Palladino; Vincenzina Nicolia; Gabor G Kovacs; Sonia Canterini; Viviana Ciraci; Andrea Fuso; Franco Mangia; Sigfrido Scarpa; Maria Teresa Fiorenza
Journal:  J Mol Neurosci       Date:  2016-11-19       Impact factor: 3.444

3.  Female gender specific association of the Reelin (RELN) gene rs7341475 variant with schizophrenia.

Authors:  Mavi Deniz Sozuguzel; Ali Sazci; Mustafa Yildiz
Journal:  Mol Biol Rep       Date:  2019-04-12       Impact factor: 2.316

4.  Identification of novel immune-relevant drug target genes for Alzheimer's Disease by combining ontology inference with network analysis.

Authors:  Zhi-Jie Han; Wei-Wei Xue; Lin Tao; Feng Zhu
Journal:  CNS Neurosci Ther       Date:  2018-08-14       Impact factor: 5.243

Review 5.  Reelin and Neuropsychiatric Disorders.

Authors:  Kazuhiro Ishii; Ken-Ichiro Kubo; Kazunori Nakajima
Journal:  Front Cell Neurosci       Date:  2016-10-18       Impact factor: 5.505

Review 6.  Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer's Disease.

Authors:  Muhammad Shahid Nadeem; Salman Hosawi; Sultan Alshehri; Mohammed M Ghoneim; Syed Sarim Imam; Bibi Nazia Murtaza; Imran Kazmi
Journal:  Biomolecules       Date:  2021-11-04

Review 7.  Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine.

Authors:  Marina A Lynch
Journal:  Front Aging Neurosci       Date:  2022-03-31       Impact factor: 5.750

8.  Identification of exon skipping events associated with Alzheimer's disease in the human hippocampus.

Authors:  Seonggyun Han; Jason E Miller; Seyoun Byun; Dokyoon Kim; Shannon L Risacher; Andrew J Saykin; Younghee Lee; Kwangsik Nho
Journal:  BMC Med Genomics       Date:  2019-01-31       Impact factor: 3.063

9.  Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data.

Authors:  Dmitry Prokopenko; Julian Hecker; Rory Kirchner; Brad A Chapman; Oliver Hoffman; Kristina Mullin; Winston Hide; Lars Bertram; Nan Laird; Dawn L DeMeo; Christoph Lange; Rudolph E Tanzi
Journal:  Sci Rep       Date:  2020-03-19       Impact factor: 4.379
  9 in total

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