| Literature DB >> 26384287 |
Jang-Sik Choi1, Hae-Jun Hwang2, Se-Won Kim2, Byung Il Lee3, Jaekyoo Lee4, Ho-Juhn Song4, Jong Sung Koh4, Jung-Ho Kim5, Phil Ho Lee6.
Abstract
A series of pyrazolylpyrimidine scaffold based Syk inhibitors were synthesized and evaluated for their biological activities and selectivity. Lead optimization efforts provided compounds with potent Syk inhibition in both enzymatic and TNF-α release assay.Entities:
Keywords: Pyrazolylpyrimidine; Rheumatoid arthritis; Spleen tyrosine kinase; Structure–activity relationship; Syk inhibitors
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Year: 2015 PMID： 26384287 DOI： 10.1016/j.bmcl.2015.09.011
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823