Alex Gileles-Hillel1, David Shoseyov1,2,3, Itzhack Polacheck4, Maya Korem4, Eitan Kerem1,2,3, Malena Cohen-Cymberknoh1,2,3. 1. Department of Pediatrics, Hadassah Hebrew-University Medical Center, Jerusalem, Israel. 2. Pediatric Pulmonology Unit, Hadassah Hebrew-University Medical Center, Jerusalem, Israel. 3. Cystic Fibrosis Center, Hadassah Hebrew-University Medical Center, Jerusalem, Israel. 4. Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew-University Medical Center, Jerusalem, Israel.
Abstract
BACKGROUND: Despite the increase in fungal isolates, the significance of chronic Candida albicans airway colonization in CF is unclear. AIM: To investigate the impact of C. albicans airway colonization on CF disease severity. METHODS: Longitudinal analysis of clinical data from CF patients followed during 2003-2009 at our CF center. Patients were stratified based on their C. albicans colonization status--chronic, intermittent, and none. RESULTS: A total of 4,244 cultures were obtained from 91 patients (mean age 19.7 years, range 5-68). The three colonization groups were similar in age, gender,and body mass index (BMI). Compared to the non-colonized group (n = 27, 30%), the chronic C. albicans colonization group (n = 34, 37%), had a significantly lower FEV1 percent predicted (74.3 ± 23.1% vs. 93.9% ± 22.2) with a higher annual rate of FEV1 decline (-1.9 ± 4.2% vs. 0.7 ± 4.5%). The patients who were intermittently colonized with C. albicans had intermediate values. CONCLUSIONS: Chronic respiratory colonization of C. albicans is associated with worsening of FEV1 in CF. Prospective studies are needed to confirm this finding and to corroborate whether indeed C. albicans drives a deleterious lung phenotype.
BACKGROUND: Despite the increase in fungal isolates, the significance of chronic Candida albicans airway colonization in CF is unclear. AIM: To investigate the impact of C. albicans airway colonization on CF disease severity. METHODS: Longitudinal analysis of clinical data from CF patients followed during 2003-2009 at our CF center. Patients were stratified based on their C. albicans colonization status--chronic, intermittent, and none. RESULTS: A total of 4,244 cultures were obtained from 91 patients (mean age 19.7 years, range 5-68). The three colonization groups were similar in age, gender,and body mass index (BMI). Compared to the non-colonized group (n = 27, 30%), the chronic C. albicans colonization group (n = 34, 37%), had a significantly lower FEV1 percent predicted (74.3 ± 23.1% vs. 93.9% ± 22.2) with a higher annual rate of FEV1 decline (-1.9 ± 4.2% vs. 0.7 ± 4.5%). The patients who were intermittently colonized with C. albicans had intermediate values. CONCLUSIONS: Chronic respiratory colonization of C. albicans is associated with worsening of FEV1 in CF. Prospective studies are needed to confirm this finding and to corroborate whether indeed C. albicans drives a deleterious lung phenotype.
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