Jong Chan Im1, Jae Pil Shin1, In Taek Kim1, Dong Ho Park2. 1. Department of Ophthalmology, School of Medicine, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea. 2. Department of Ophthalmology, School of Medicine, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, South Korea. sarasate2222@gmail.com.
Abstract
PURPOSE: To measure unaffected retinal vessel diameter in eyes with macular edema (ME) secondary to branch retinal vein occlusion (BRVO) after intravitreal injection with bevacizumab (IVB). METHODS: Patients with BRVO-induced ME who responded to IVB were assessed at baseline and 1, 3, and 6 months. In both eyes, the diameters of the largest arteriole and venule in all quadrants (except occlusion quadrant) were measured by using a computer-assisted method. The same vessels chosen at baseline were measured at each follow-up examination. RESULTS: Forty-two eyes were participated. At baseline, venular diameters of unaffected quadrants in eyes with BRVO were larger than the venules in the corresponding quadrant of the fellow eyes (p < 0.05, respectively). The venular diameters in all quadrants of the affected eyes decreased significantly relative to baseline after IVB (p < 0.05 respectively). Twenty-two eyes (52.4 %) developed recurrent ME. On recurrence at 3 (n = 15, 35.7 %) or 6 months (n = 7, 16.7 %), the unaffected venular diameters increased significantly (p < 0.05 respectively). These diameters again decreased significantly after a second IVB (p < 0.05 respectively). CONCLUSION: Unaffected retinal venular diameters associate with the course of BRVO with ME. This may help elucidate the pathological mechanism underlying BRVO.
PURPOSE: To measure unaffected retinal vessel diameter in eyes with macular edema (ME) secondary to branch retinal vein occlusion (BRVO) after intravitreal injection with bevacizumab (IVB). METHODS:Patients with BRVO-induced ME who responded to IVB were assessed at baseline and 1, 3, and 6 months. In both eyes, the diameters of the largest arteriole and venule in all quadrants (except occlusion quadrant) were measured by using a computer-assisted method. The same vessels chosen at baseline were measured at each follow-up examination. RESULTS: Forty-two eyes were participated. At baseline, venular diameters of unaffected quadrants in eyes with BRVO were larger than the venules in the corresponding quadrant of the fellow eyes (p < 0.05, respectively). The venular diameters in all quadrants of the affected eyes decreased significantly relative to baseline after IVB (p < 0.05 respectively). Twenty-two eyes (52.4 %) developed recurrent ME. On recurrence at 3 (n = 15, 35.7 %) or 6 months (n = 7, 16.7 %), the unaffected venular diameters increased significantly (p < 0.05 respectively). These diameters again decreased significantly after a second IVB (p < 0.05 respectively). CONCLUSION: Unaffected retinal venular diameters associate with the course of BRVO with ME. This may help elucidate the pathological mechanism underlying BRVO.
Authors: L L Lim; N Cheung; J J Wang; F M A Islam; P Mitchell; S M Saw; T Aung; T Y Wong Journal: Br J Ophthalmol Date: 2008-08-06 Impact factor: 4.638
Authors: R G Tilton; K C Chang; W S LeJeune; C C Stephan; T A Brock; J R Williamson Journal: Invest Ophthalmol Vis Sci Date: 1999-03 Impact factor: 4.799