Fengji Geng1, Xiaoqin Mai2, Jianying Zhan3, Lin Xu3, Zhengyan Zhao3, Michael Georgieff4, Jie Shao5, Betsy Lozoff6. 1. Department of Psychology, University of Maryland, College Park, MD. 2. Department of Psychology, Renmin University of China, Beijing, China. 3. Department of Child Health Care, Children's Hospital Zhejiang University School of Medicine, Hangzhou, China. 4. Department of Pediatrics, University of Minnesota, Minneapolis, MN. 5. Department of Child Health Care, Children's Hospital Zhejiang University School of Medicine, Hangzhou, China. Electronic address: shaojie@zju.edu.cn. 6. Center for Human Growth and Development, University of Michigan, Ann Arbor, MI; Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI.
Abstract
OBJECTIVE: To assess the effects of fetal-neonatal iron deficiency on recognition memory in early infancy. Perinatal iron deficiency delays or disrupts hippocampal development in animal models and thus may impair related neural functions in human infants, such as recognition memory. STUDY DESIGN: Event-related potentials were used in an auditory recognition memory task to compare 2-month-old Chinese infants with iron sufficiency or deficiency at birth. Fetal-neonatal iron deficiency was defined 2 ways: high zinc protoporphyrin/heme ratio (ZPP/H > 118 μmol/mol) or low serum ferritin (<75 μg/L) in cord blood. Late slow wave was used to measure infant recognition of mother's voice. RESULTS: Event related potentials patterns differed significantly for fetal-neonatal iron deficiency as defined by high cord ZPP/H but not low ferritin. Comparing 35 infants with iron deficiency (ZPP/H > 118 μmol/mol) to 92 with lower ZPP/H (iron-sufficient), only infants with iron sufficiency showed larger late slow wave amplitude for stranger's voice than mother's voice in frontal-central and parietal-occipital locations, indicating the recognition of mother's voice. CONCLUSIONS: Infants with iron sufficiency showed electrophysiological evidence of recognizing their mother's voice, whereas infants with fetal-neonatal iron deficiency did not. Their poorer auditory recognition memory at 2 months of age is consistent with effects of fetal-neonatal iron deficiency on the developing hippocampus.
OBJECTIVE: To assess the effects of fetal-neonatal iron deficiency on recognition memory in early infancy. Perinatal iron deficiency delays or disrupts hippocampal development in animal models and thus may impair related neural functions in humaninfants, such as recognition memory. STUDY DESIGN: Event-related potentials were used in an auditory recognition memory task to compare 2-month-old Chinese infants with iron sufficiency or deficiency at birth. Fetal-neonatal iron deficiency was defined 2 ways: high zinc protoporphyrin/heme ratio (ZPP/H > 118 μmol/mol) or low serum ferritin (<75 μg/L) in cord blood. Late slow wave was used to measure infant recognition of mother's voice. RESULTS: Event related potentials patterns differed significantly for fetal-neonatal iron deficiency as defined by high cord ZPP/H but not low ferritin. Comparing 35 infants with iron deficiency (ZPP/H > 118 μmol/mol) to 92 with lower ZPP/H (iron-sufficient), only infants with iron sufficiency showed larger late slow wave amplitude for stranger's voice than mother's voice in frontal-central and parietal-occipital locations, indicating the recognition of mother's voice. CONCLUSIONS:Infants with iron sufficiency showed electrophysiological evidence of recognizing their mother's voice, whereas infants with fetal-neonatal iron deficiency did not. Their poorer auditory recognition memory at 2 months of age is consistent with effects of fetal-neonatal iron deficiency on the developing hippocampus.
Authors: Tsunenobu Tamura; Robert L Goldenberg; Jinrong Hou; Kelley E Johnston; Suzanne P Cliver; Sharon L Ramey; Kathleen G Nelson Journal: J Pediatr Date: 2002-02 Impact factor: 4.406
Authors: Eliza L Congdon; Alissa Westerlund; Cecilia R Algarin; Patricio D Peirano; Matthew Gregas; Betsy Lozoff; Charles A Nelson Journal: J Pediatr Date: 2012-01-11 Impact factor: 4.406
Authors: Jie Shao; Jingan Lou; Raghavendra Rao; Michael K Georgieff; Niko Kaciroti; Barbara T Felt; Zheng-Yan Zhao; Betsy Lozoff Journal: J Nutr Date: 2012-09-26 Impact factor: 4.798
Authors: Ashajyothi M Siddappa; Michael K Georgieff; Sandi Wewerka; Cathy Worwa; Charles A Nelson; Raye-Ann Deregnier Journal: Pediatr Res Date: 2004-06 Impact factor: 3.756
Authors: Sean Lynch; Christine M Pfeiffer; Michael K Georgieff; Gary Brittenham; Susan Fairweather-Tait; Richard F Hurrell; Harry J McArdle; Daniel J Raiten Journal: J Nutr Date: 2018-06-01 Impact factor: 4.798
Authors: Sandra E Juul; Phuong T Vu; Bryan A Comstock; Rajan Wadhawan; Dennis E Mayock; Sherry E Courtney; Tonya Robinson; Kaashif A Ahmad; Ellen Bendel-Stenzel; Mariana Baserga; Edmund F LaGamma; L Corbin Downey; Michael O'Shea; Raghavendra Rao; Nancy Fahim; Andrea Lampland; Ivan D Frantz; Janine Khan; Michael Weiss; Maureen M Gilmore; Robin Ohls; Nishant Srinivasan; Jorge E Perez; Victor McKay; Patrick J Heagerty Journal: JAMA Pediatr Date: 2020-10-01 Impact factor: 16.193
Authors: Ashajyothi M Siddappa; Rose M Olson; Miriam Spector; Elise Northrop; Tara Zamora; Ann M Brearley; Michael K Georgieff; Raghavendra Rao Journal: J Pediatr Date: 2020-05-14 Impact factor: 4.406