Literature DB >> 26381590

Regioselective Green Electrochemical Approach to the Synthesis of Nitroacetaminophen Derivatives.

Eslam Salahifar1, Davood Nematollahi1, Mehdi Bayat1, Amir Mahyari1, Hadi Amiri Rudbari2.   

Abstract

A regioselective green synthesis of nitroacetaminophen derivatives was carried out by electrochemical oxidation of acetaminophen, N-(2-hydroxyphenyl)acetamide, and 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone in the presence of nitrite ion as a nucleophile. The present work has led to the development of a reagentless green and facile electrochemical method for the synthesis of some nitroacetaminophen derivatives.

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Year:  2015        PMID: 26381590     DOI: 10.1021/acs.orglett.5b01837

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


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