OBJECTIVE: To characterized the gene polymorphisms of connexin 40 (cx40) and angiotensin II receptor type 1 (AT1R) in Chongming adults with atrial fibrillation (AF) and to explore their relationships with AF. METHODS: 82 patients with AF, and 82 subjects without AF were enrolled. Polymorphisms of cx40 G-44A and AT1 A1166C were detected. Moreover, several samples were randomly selected to validate the gene polymorphisms of cx40 and AT1. RESULTS: Genotypes AA, AG and GG of cx40 G-44A were found in both AF patients and controls. The frequencies of genotypes AA, AG and GG were 39%, 29% and 32%, respectively, in AF patients and 31%, 35% and 34%, respectively in controls. The frequencies of alleles A and G were 54% and 46%, respectively in AF patients and 48% and 52%, respectively, in controls (P < 0.05). The risk for AF in patients with allele A increased 1.31 times (OR = 1.31, P < 0.05). The frequencies of genotypes AA, AC and CC were 88%, 8% and 4%, respectively in AF patients and 93%, 6% and 1%, respectively in controls. The frequencies of alleles A and C were 92% and 8%, respectively in AF patients and 96% and 4%, respectively in controls (P < 0.05). More AF patients had allele C as compared to controls. The risk for AF increased by 1.43 times in patients with allele C (OR = 1.43, P < 0.05). CONCLUSION: There were relationships between gene polymorphisms of cx40 and AT1 and AF in Chongming adults. Allele A of cx40 G-44A and allele C of AT1 A1166C significantly increase the risk for AF.
OBJECTIVE: To characterized the gene polymorphisms of connexin 40 (cx40) and angiotensin II receptor type 1 (AT1R) in Chongming adults with atrial fibrillation (AF) and to explore their relationships with AF. METHODS: 82 patients with AF, and 82 subjects without AF were enrolled. Polymorphisms of cx40G-44A and AT1A1166C were detected. Moreover, several samples were randomly selected to validate the gene polymorphisms of cx40 and AT1. RESULTS: Genotypes AA, AG and GG of cx40G-44A were found in both AFpatients and controls. The frequencies of genotypes AA, AG and GG were 39%, 29% and 32%, respectively, in AFpatients and 31%, 35% and 34%, respectively in controls. The frequencies of alleles A and G were 54% and 46%, respectively in AFpatients and 48% and 52%, respectively, in controls (P < 0.05). The risk for AF in patients with allele A increased 1.31 times (OR = 1.31, P < 0.05). The frequencies of genotypes AA, AC and CC were 88%, 8% and 4%, respectively in AFpatients and 93%, 6% and 1%, respectively in controls. The frequencies of alleles A and C were 92% and 8%, respectively in AFpatients and 96% and 4%, respectively in controls (P < 0.05). More AFpatients had allele C as compared to controls. The risk for AF increased by 1.43 times in patients with allele C (OR = 1.43, P < 0.05). CONCLUSION: There were relationships between gene polymorphisms of cx40 and AT1 and AF in Chongming adults. Allele A of cx40G-44A and allele C of AT1A1166C significantly increase the risk for AF.
Entities:
Keywords:
Atrial fibrillation; angiotensin ii receptor type 1; connexin; gene polymorphism
Authors: Tomonori Igarashi; J Emanuel Finet; Ayano Takeuchi; Yoshihisa Fujino; Maria Strom; Ian D Greener; David S Rosenbaum; J Kevin Donahue Journal: Circulation Date: 2011-12-08 Impact factor: 29.690
Authors: S Dhein; S Rothe; A Busch; D M Rojas Gomez; A Boldt; A Reutemann; T Seidel; A Salameh; B Pfannmüller; A Rastan; M Kostelka; F W Mohr Journal: Br J Pharmacol Date: 2011-09 Impact factor: 8.739