Yan Liu1, Jian Zhang2, Zhong-Ming Jia3, Ji-Chang Li1, Chun-Hua Dong1, Yong-Mei Li1. 1. Department of Gynecology, Binzhou People's Hospital Binzhou 256610, China. 2. Department of Pathology, Binzhou People's Hospital Binzhou 256610, China. 3. Department of Thyroid and Breast Surgery, Affiliated Hospital of Binzhou Medical College Binzhou 256603, China.
Abstract
OBJECTIVE: To analyze the distribution of HLA-DRB1 and HLA-DQB1 alleles and its correlation with IFN-γ, IL-2, IL-6, IL-10 in HPV16 infected women with advanced cervical carcinoma. METHODS: We collected 137 blood samples of cervical carcinoma patients diagnosed by pathology as cervical cancer in stage IIb-IVb before the treatment, and we gathered 175 blood samples of healthy women living in the local. We determined the genetic subtypes of HLA-DRB1 and HLA-DQB1, and we measured the concentration of IFN-γ, IL-2, IL-6 and IL-10. We compared the difference of cytokines in patients with different clinical stages and the healthy in the control group. According to genetic subtypes of HLA-DRB1 and HLA-DQB1, we also compared the concentration of cytokine (CK) in different genetic subtypes. RESULTS: Eight HLA-DRB1 alleles and four HLA-DQB1 alleles were found. There were not significant differences between each allele in the concentration of IFN-γ, IL-2, IL-6, and IL-10. CONCLUSION: HLA-DRB1*07, HLA-DQB1*02 and HLA-DQB1*03 were the differentially expressed gene in HPV16 infected patients with advanced cervical cancer. There may be correlations between the occurrence, development of cervical cancer and IFN-γ, IL-2, IL-6, IL-10.
OBJECTIVE: To analyze the distribution of HLA-DRB1 and HLA-DQB1 alleles and its correlation with IFN-γ, IL-2, IL-6, IL-10 in HPV16 infected women with advanced cervical carcinoma. METHODS: We collected 137 blood samples of cervical carcinomapatients diagnosed by pathology as cervical cancer in stage IIb-IVb before the treatment, and we gathered 175 blood samples of healthy women living in the local. We determined the genetic subtypes of HLA-DRB1 and HLA-DQB1, and we measured the concentration of IFN-γ, IL-2, IL-6 and IL-10. We compared the difference of cytokines in patients with different clinical stages and the healthy in the control group. According to genetic subtypes of HLA-DRB1 and HLA-DQB1, we also compared the concentration of cytokine (CK) in different genetic subtypes. RESULTS: Eight HLA-DRB1 alleles and four HLA-DQB1 alleles were found. There were not significant differences between each allele in the concentration of IFN-γ, IL-2, IL-6, and IL-10. CONCLUSION:HLA-DRB1*07, HLA-DQB1*02 and HLA-DQB1*03 were the differentially expressed gene in HPV16 infected patients with advanced cervical cancer. There may be correlations between the occurrence, development of cervical cancer and IFN-γ, IL-2, IL-6, IL-10.
Authors: Margaret M Madeleine; Lisa G Johnson; Anajane G Smith; John A Hansen; Brenda B Nisperos; Sue Li; Lue-Ping Zhao; Janet R Daling; Stephen M Schwartz; Denise A Galloway Journal: Cancer Res Date: 2008-05-01 Impact factor: 12.701
Authors: María García-Álvarez; Miguel Alcoceba; Miriam López-Parra; Noemí Puig; Alicia Antón; Ana Balanzategui; Isabel Prieto-Conde; Cristina Jiménez; María E Sarasquete; M Carmen Chillón; María Laura Gutiérrez; Rocío Corral; José María Alonso; José Antonio Queizán; Julia Vidán; Emilia Pardal; María Jesús Peñarrubia; José M Bastida; Ramón García-Sanz; Luis Marín; Marcos González Journal: PLoS One Date: 2017-03-01 Impact factor: 3.240