Jianhua Gong1, Qian Xu1, Fengqi Hu1, Hai Yuan1. 1. Department of Nephrology, Xiangyang Central Hospital, Hubei University of Arts and Science Hubei, China.
Abstract
OBJECTIVE: To investigate the association of β-fibrinogen gene polymorphism with plasma fibrinogen and allergic purpura nephritis. METHODS: We designed a case-control study (334 case and 300 control) to genotype the β-fibrinogen gene -455G/A polymorphism. The genotype and allele frequencies between the case and control group were compared. And we also compared the Fg concentration between different genotype. RESULTS: In the case group, there were 143 cases of GA type, accounting for 42.8%; there were 168 cases of GG type, accounting for 50.3%; there were 23 cases of AA type, accounting for 6.9%. While in the control group, GG type was the most common. There were 228 cases of GG type, accounting for 76%; there were 66 cases of GA type, accounting for 22%; there was 6 case of AA type, accounting for 2%. The frequency of Fgβ-455G/A genotype between the two groups showed statistical significance (P<0.05). The levels of plasma Fg in the two groups showed statistical significance (P<0.01). In HSPN group Fgβ GA and AA-type the concentration of Fg [(4.2 ± 0.5) g/L], compared with the GG genotype [(3.1 ± 0.4) g/L], was significantly increased with statistical significance (P<0.01). CONCLUSION: The Fgβ-455G/A polymorphism was associated with the risk for HSPN and Fg concentration.
OBJECTIVE: To investigate the association of β-fibrinogen gene polymorphism with plasma fibrinogen and allergic purpura nephritis. METHODS: We designed a case-control study (334 case and 300 control) to genotype the β-fibrinogen gene -455G/A polymorphism. The genotype and allele frequencies between the case and control group were compared. And we also compared the Fg concentration between different genotype. RESULTS: In the case group, there were 143 cases of GA type, accounting for 42.8%; there were 168 cases of GG type, accounting for 50.3%; there were 23 cases of AA type, accounting for 6.9%. While in the control group, GG type was the most common. There were 228 cases of GG type, accounting for 76%; there were 66 cases of GA type, accounting for 22%; there was 6 case of AA type, accounting for 2%. The frequency of Fgβ-455G/A genotype between the two groups showed statistical significance (P<0.05). The levels of plasma Fg in the two groups showed statistical significance (P<0.01). In HSPN group Fgβ GA and AA-type the concentration of Fg [(4.2 ± 0.5) g/L], compared with the GG genotype [(3.1 ± 0.4) g/L], was significantly increased with statistical significance (P<0.01). CONCLUSION: The Fgβ-455G/A polymorphism was associated with the risk for HSPN and Fg concentration.
Authors: Kelly V Liang; Eddie L Greene; Liem Som Oei; Matthew Lewin; Donna Lager; Sanjeev Sethi Journal: Am J Kidney Dis Date: 2007-04 Impact factor: 8.860