Nasser M Al-Daghri1, Shakilur Rahman2, Osama E Amer2, Omar S Al-Attas1, Philip G McTernan3, Majed S Alokail1. 1. Department of Biochemistry, Biomarkers Research Program, College of Science, King Saud University Riyadh 11451, Saudi Arabia ; Department of Biochemistry, Prince Mutaib Chair for Biomarkers of Osteoporosis, College of Science, King Saud University Riyadh 11451, Saudi Arabia. 2. Department of Biochemistry, Biomarkers Research Program, College of Science, King Saud University Riyadh 11451, Saudi Arabia. 3. Division of Translational and Systems Medicine, Warwick Medical School, University of Warwick Coventry, UK.
Abstract
BACKGROUND AND OBJECTIVE: Leptin and vitamin D play an important role in obesity development and metabolic effects; however, the association between leptin and vitamin D is not well studied in Saudi subjects. We aimed to examine gender dependent association between serum leptin and 25-OH-VitD in adult Saudi subjects. SUBJECTS AND METHODS: For this cross-sectional study in a cohort of 259 Saudi adults (100 male, age: 46.4 ± 0.9 yr [mean ± SD]; BMI: 27.8 ± 0.5 Kg/m(2)) and (159 female, age 46.5 ± 0.7 [mean ± SD]; BMI: 28.4 ± 0.4 Kg/m(2)) anthropometrics, fasting bloods, and biochemical data were collected. Serum leptin and 25-hydroxyvitamin D (vitamin D or 25-OH-VitD) were quantified using an enzyme-linked immunosorbent assay. RESULTS: Circulating leptin and vitamin D levels were significantly higher in females compared to male (P<0.001 and P<0.01 respectively). Visceral adiposity index (VAI), triglycerides and total cholesterol were significantly higher (P<0.05, P<0.001, and P<0.05, respectively) while HDL-cholesterol were lower (P<0.001) in male compared to female subjects. In males, vitamin D levels were positively associated with leptin (r = 0.196, P<0.05). CONCLUSION: Vitamin D was positively associated with serum leptin in male Saudi subjects. Additionally, male subjects were found to be dyslipidemic, which might be a responsible factor for this discordant association between vitamin D and leptin in Saudi population.
BACKGROUND AND OBJECTIVE:Leptin and vitamin D play an important role in obesity development and metabolic effects; however, the association between leptin and vitamin D is not well studied in Saudi subjects. We aimed to examine gender dependent association between serum leptin and 25-OH-VitD in adult Saudi subjects. SUBJECTS AND METHODS: For this cross-sectional study in a cohort of 259 Saudi adults (100 male, age: 46.4 ± 0.9 yr [mean ± SD]; BMI: 27.8 ± 0.5 Kg/m(2)) and (159 female, age 46.5 ± 0.7 [mean ± SD]; BMI: 28.4 ± 0.4 Kg/m(2)) anthropometrics, fasting bloods, and biochemical data were collected. Serum leptin and 25-hydroxyvitamin D (vitamin D or 25-OH-VitD) were quantified using an enzyme-linked immunosorbent assay. RESULTS: Circulating leptin and vitamin D levels were significantly higher in females compared to male (P<0.001 and P<0.01 respectively). Visceral adiposity index (VAI), triglycerides and total cholesterol were significantly higher (P<0.05, P<0.001, and P<0.05, respectively) while HDL-cholesterol were lower (P<0.001) in male compared to female subjects. In males, vitamin D levels were positively associated with leptin (r = 0.196, P<0.05). CONCLUSION:Vitamin D was positively associated with serum leptin in male Saudi subjects. Additionally, male subjects were found to be dyslipidemic, which might be a responsible factor for this discordant association between vitamin D and leptin in Saudi population.
Entities:
Keywords:
Leptin; Saudi subjects; dyslipidemia; vitamin D
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