Yaosheng Liu1, Zhicheng Zhang2, Shubin Liu1, Xiuyun Su1, Shiguo Zhou3. 1. Department of Orthopedics, 307 Hospital of PLA Beijing, People's Republic of China. 2. PLA Institute of Orthopedics, Beijing military general hospital Beijing, People's Republic of China. 3. Statistics Room, Capital Medical University Affiliated Beijing Friendship Hospital Beijing, People's Republic of China.
Abstract
BACKGROUND: VEGF plays an important role in bone formation and repair. However, the effects of VEGF -634G/C polymorphisms on the pathogenesis of osteonecrosis of the femoral head (ONFH) were not conclusive. Our research was aimed to further analyze the association of VEGF -634G/C polymorphism with ONFH risk. METHODS: The relevant articles were searched in PubMed, Elsevier, EMBASE, Web of Science and Chinese National Knowledge Infrastructure (CNKI) database. And a total of 692 cases and 875 controls were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the correlation of VEGF -634G/C polymorphism and ONFH susceptibility. Chi-square based Q-statistic test was used to evaluate heterogeneity among the studies. The random-effects model or fixed-effects model was used depending on heterogeneity. RESULTS: The sensitivity analysis and publication bias test indicated that our results were stable and credible. And the results suggested that VEGF -634G/C polymorphism was significantly related with increased risk for ONFH in Asian population (CC versus GG: OR=1.34, 95% CI=1.02-1.76). CONCLUSION: The results indicated that VEGF -634G/C polymorphism might serve as genetic-susceptibility factor for ONFH.
BACKGROUND:VEGF plays an important role in bone formation and repair. However, the effects of VEGF-634G/C polymorphisms on the pathogenesis of osteonecrosis of the femoral head (ONFH) were not conclusive. Our research was aimed to further analyze the association of VEGF-634G/C polymorphism with ONFH risk. METHODS: The relevant articles were searched in PubMed, Elsevier, EMBASE, Web of Science and Chinese National Knowledge Infrastructure (CNKI) database. And a total of 692 cases and 875 controls were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the correlation of VEGF-634G/C polymorphism and ONFH susceptibility. Chi-square based Q-statistic test was used to evaluate heterogeneity among the studies. The random-effects model or fixed-effects model was used depending on heterogeneity. RESULTS: The sensitivity analysis and publication bias test indicated that our results were stable and credible. And the results suggested that VEGF-634G/C polymorphism was significantly related with increased risk for ONFH in Asian population (CC versus GG: OR=1.34, 95% CI=1.02-1.76). CONCLUSION: The results indicated that VEGF-634G/C polymorphism might serve as genetic-susceptibility factor for ONFH.
Entities:
Keywords:
VEGF; osteonecrosis of the femoral head; polymorphism
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