Literature DB >> 26379023

Small-molecule inhibitors: bULKing up mTOR inhibition.

Jonathan M Goodwin1, Leon O Murphy1.   

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Year:  2015        PMID： 26379023     DOI： 10.1038/nchembio.1909

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  13 in total

1.  A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.

Authors:  Baptiste Ronan; Odile Flamand; Lionel Vescovi; Christine Dureuil; Laurence Durand; Florence Fassy; Marie-France Bachelot; Annabelle Lamberton; Magali Mathieu; Thomas Bertrand; Jean-Pierre Marquette; Youssef El-Ahmad; Bruno Filoche-Romme; Laurent Schio; Carlos Garcia-Echeverria; Hélène Goulaouic; Benoit Pasquier
Journal:  Nat Chem Biol       Date:  2014-10-19       Impact factor: 15.040

Review 2.  Getting ready for building: signaling and autophagosome biogenesis.

Authors:  Adi Abada; Zvulun Elazar
Journal:  EMBO Rep       Date:  2014-07-15       Impact factor: 8.807

3.  AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

Authors:  Joungmok Kim; Mondira Kundu; Benoit Viollet; Kun-Liang Guan
Journal:  Nat Cell Biol       Date:  2011-01-23       Impact factor: 28.824

Review 4.  Autophagy in malignant transformation and cancer progression.

Authors:  Lorenzo Galluzzi; Federico Pietrocola; José Manuel Bravo-San Pedro; Ravi K Amaravadi; Eric H Baehrecke; Francesco Cecconi; Patrice Codogno; Jayanta Debnath; David A Gewirtz; Vassiliki Karantza; Alec Kimmelman; Sharad Kumar; Beth Levine; Maria Chiara Maiuri; Seamus J Martin; Josef Penninger; Mauro Piacentini; David C Rubinsztein; Hans-Uwe Simon; Anne Simonsen; Andrew M Thorburn; Guillermo Velasco; Kevin M Ryan; Guido Kroemer
Journal:  EMBO J       Date:  2015-02-23       Impact factor: 11.598

5.  Everolimus for advanced pancreatic neuroendocrine tumors.

Authors:  James C Yao; Manisha H Shah; Tetsuhide Ito; Catherine Lombard Bohas; Edward M Wolin; Eric Van Cutsem; Timothy J Hobday; Takuji Okusaka; Jaume Capdevila; Elisabeth G E de Vries; Paola Tomassetti; Marianne E Pavel; Sakina Hoosen; Tomas Haas; Jeremie Lincy; David Lebwohl; Kjell Öberg
Journal:  N Engl J Med       Date:  2011-02-10       Impact factor: 91.245

6.  Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.

Authors:  William E Dowdle; Beat Nyfeler; Jane Nagel; Robert A Elling; Shanming Liu; Ellen Triantafellow; Suchithra Menon; Zuncai Wang; Ayako Honda; Gwynn Pardee; John Cantwell; Catherine Luu; Ivan Cornella-Taracido; Edmund Harrington; Peter Fekkes; Hong Lei; Qing Fang; Mary Ellen Digan; Debra Burdick; Andrew F Powers; Stephen B Helliwell; Simon D'Aquin; Julie Bastien; Henry Wang; Dmitri Wiederschain; Jenny Kuerth; Philip Bergman; David Schwalb; Jason Thomas; Savuth Ugwonali; Fred Harbinski; John Tallarico; Christopher J Wilson; Vic E Myer; Jeffery A Porter; Dirksen E Bussiere; Peter M Finan; Mark A Labow; Xiaohong Mao; Lawrence G Hamann; Brendan D Manning; Reginald A Valdez; Thomas Nicholson; Markus Schirle; Mark S Knapp; Erin P Keaney; Leon O Murphy
Journal:  Nat Cell Biol       Date:  2014-10-19       Impact factor: 28.824

Review 7.  Autophagy modulation as a potential therapeutic target for diverse diseases.

Authors:  David C Rubinsztein; Patrice Codogno; Beth Levine
Journal:  Nat Rev Drug Discov       Date:  2012-09       Impact factor: 84.694

8.  Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

Authors:  Katy J Petherick; Owen J L Conway; Chido Mpamhanga; Simon A Osborne; Ahmad Kamal; Barbara Saxty; Ian G Ganley
Journal:  J Biol Chem       Date:  2015-04-01       Impact factor: 5.157

9.  Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase.

Authors:  Daniel Papinski; Martina Schuschnig; Wolfgang Reiter; Larissa Wilhelm; Christopher A Barnes; Alessio Maiolica; Isabella Hansmann; Thaddaeus Pfaffenwimmer; Monika Kijanska; Ingrid Stoffel; Sung Sik Lee; Andrea Brezovich; Jane Hua Lou; Benjamin E Turk; Ruedi Aebersold; Gustav Ammerer; Matthias Peter; Claudine Kraft
Journal:  Mol Cell       Date:  2014-01-16       Impact factor: 17.970

10.  Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.

Authors:  Ruzica Bago; Nazma Malik; Michael J Munson; Alan R Prescott; Paul Davies; Eeva Sommer; Natalia Shpiro; Richard Ward; Darren Cross; Ian G Ganley; Dario R Alessi
Journal:  Biochem J       Date:  2014-11-01       Impact factor: 3.857
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