Literature DB >> 26378170

Role of Substitutions in the Hemagglutinin in the Emergence of the 1968 Pandemic Influenza Virus.

Sjouke Van Poucke1, Jennifer Doedt2, Jan Baumann2, Yu Qiu1, Tatyana Matrosovich2, Hans-Dieter Klenk2, Kristien Van Reeth3, Mikhail Matrosovich4.   

Abstract

Hemagglutinin (HA) of H3N2/1968 pandemic influenza viruses differs from the putative avian precursor by seven amino acid substitutions. Substitutions Q226L and G228S are known to be essential for adaptation of avian HA to mammals. We found that introduction of avian-virus-like amino acids at five other HA positions (positions 62, 81, 92, 144, and 193) of A/Hong Kong/1/1968 virus decreased viral replication in human cells and transmission in pigs. Thus, substitutions at some of these positions facilitated emergence of the pandemic virus.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26378170      PMCID： PMC4645308          DOI： 10.1128/JVI.01292-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  38 in total

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Authors:  R G Webster; W J Bean; O T Gorman; T M Chambers; Y Kawaoka
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4.  A DNA transfection system for generation of influenza A virus from eight plasmids.

Authors:  E Hoffmann; G Neumann; Y Kawaoka; G Hobom; R G Webster
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5.  Membrane fusion activity of the influenza virus hemagglutinin. The low pH-induced conformational change.

Authors:  R W Doms; A Helenius; J White
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8.  Evolution of the H3 influenza virus hemagglutinin from human and nonhuman hosts.

Authors:  W J Bean; M Schell; J Katz; Y Kawaoka; C Naeve; O Gorman; R G Webster
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9.  Infectious entry pathway of influenza virus in a canine kidney cell line.

Authors:  K S Matlin; H Reggio; A Helenius; K Simons
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3.  Enhanced Human-Type Receptor Binding by Ferret-Transmissible H5N1 with a K193T Mutation.

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5.  pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.

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6.  Fifty Years of Influenza A(H3N2) Following the Pandemic of 1968.

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7.  Three mutations switch H7N9 influenza to human-type receptor specificity.

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8.  Characterization and Evolutionary Analysis of a Novel H3N2 Influenza A Virus Glycosylation Motif in Southern China.

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9.  The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance.

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Review 10.  H3N2 influenza viruses in humans: Viral mechanisms, evolution, and evaluation.

Authors:  James D Allen; Ted M Ross
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