| Literature DB >> 26377891 |
Sunny Shin1, Yair Argon2.
Abstract
Bacterial infection induces inflammasome activation and release of interleukin-1 (IL-1) cytokines. Bronner et al. (2015) show that during Brucella abortus infection, an endoplasmic reticulum stress sensor, IRE1α, initiates NLRP3- and caspase-2-mediated mitochondrial damage that potentiates NLRP3 inflammasome assembly.Entities:
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Year: 2015 PMID： 26377891 DOI： 10.1016/j.immuni.2015.08.027
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745