B E Mouthaan1, M A van 't Klooster2, D Keizer1, G J Hebbink1, F S S Leijten3, C H Ferrier3, M J A M van Putten4, M Zijlmans5, G J M Huiskamp3. 1. Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands; MIRA, Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands. 2. Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: m.a.vanhetklooster-2@umcutrecht.nl. 3. Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands. 4. MIRA, Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands. 5. Brain Center Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands; SEIN - Stichting Epilepsie Instellingen Nederland, Heemstede, The Netherlands.
Abstract
OBJECTIVE: Single Pulse Electrical Stimulation (SPES) probes epileptogenic cortex during electrocorticography. Two SPES responses are described: pathological delayed responses (DR, >100 ms) associated with the seizure onset zone (SOZ) and physiological early responses (ER, <100 ms) that map cortical connectivity. We analyzed properties of ERs, including frequencies >80 Hz, in the SOZ and seizure propagation areas. METHODS: We used data from 12 refractory epilepsy patients. SPES consisted of 10 pulses of 1 ms, 4-8 mA and 5s interval on adjacent electrodes pairs. Data were available at 2048 samples/s for six and 512 samples/s (22 bits) for eight patients and analyzed in the time-frequency (TF) and time-domain (TD). RESULTS: Electrodes with ERs were stronger associated with SOZ than non-SOZ electrodes. ERs with frequency content >80 Hz exist and are specific for SOZ channels. ERs evoked by stimulation of seizure onset electrodes were associated with electrodes involved in seizure propagation. CONCLUSION: Analysis of ERs can reveal aspects of pathology, manifested by association with seizure propagation and areas with high ER numbers that coincide with the SOZ. SIGNIFICANCE: Not only DRs, but also ERs could have clinical value for mapping epileptogenic cortex and help to unravel aspects of the epileptic network.
OBJECTIVE: Single Pulse Electrical Stimulation (SPES) probes epileptogenic cortex during electrocorticography. Two SPES responses are described: pathological delayed responses (DR, >100 ms) associated with the seizure onset zone (SOZ) and physiological early responses (ER, <100 ms) that map cortical connectivity. We analyzed properties of ERs, including frequencies >80 Hz, in the SOZ and seizure propagation areas. METHODS: We used data from 12 refractory epilepsypatients. SPES consisted of 10 pulses of 1 ms, 4-8 mA and 5s interval on adjacent electrodes pairs. Data were available at 2048 samples/s for six and 512 samples/s (22 bits) for eight patients and analyzed in the time-frequency (TF) and time-domain (TD). RESULTS: Electrodes with ERs were stronger associated with SOZ than non-SOZ electrodes. ERs with frequency content >80 Hz exist and are specific for SOZ channels. ERs evoked by stimulation of seizure onset electrodes were associated with electrodes involved in seizure propagation. CONCLUSION: Analysis of ERs can reveal aspects of pathology, manifested by association with seizure propagation and areas with high ER numbers that coincide with the SOZ. SIGNIFICANCE: Not only DRs, but also ERs could have clinical value for mapping epileptogenic cortex and help to unravel aspects of the epileptic network.
Authors: Bornali Kundu; Tyler S Davis; Brian Philip; Elliot H Smith; Amir Arain; Angela Peters; Blake Newman; Christopher R Butson; John D Rolston Journal: Brain Stimul Date: 2020-06-03 Impact factor: 8.955
Authors: D J Caldwell; J A Cronin; R P N Rao; K L Collins; K E Weaver; A L Ko; J G Ojemann; J N Kutz; B W Brunton Journal: J Neural Eng Date: 2020-04-09 Impact factor: 5.379
Authors: Jurgen Hebbink; Dorien van Blooijs; Geertjan Huiskamp; Frans S S Leijten; Stephan A van Gils; Hil G E Meijer Journal: Brain Topogr Date: 2018-12-06 Impact factor: 3.020
Authors: Dorien van Blooijs; Frans S S Leijten; Peter C van Rijen; Hil G E Meijer; Geertjan J M Huiskamp Journal: Hum Brain Mapp Date: 2018-07-21 Impact factor: 5.038