Literature DB >> 26375212

Genes influence the amplitude and timing of brain hemodynamic responses.

Zuyao Y Shan1, Anna A E Vinkhuyzen2, Paul M Thompson3, Katie L McMahon1, Gabriëlla A M Blokland4, Greig I de Zubicaray5, Vince Calhoun6, Nicholas G Martin7, Peter M Visscher2, Margaret J Wright7, David C Reutens8.   

Abstract

In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%-51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Hemodynamic response function (HRF); Heritability; Neurovascular coupling; Twin study

Mesh：

Year:  2015        PMID： 26375212      PMCID： PMC4859312          DOI： 10.1016/j.neuroimage.2015.09.016

Source DB:  PubMed          Journal:  Neuroimage        ISSN： 1053-8119            Impact factor:   6.556


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