Literature DB >> 26374995

Rosmarinic acid mitigates signs of systemic oxidative stress in streptozotocin-induced diabetes in rats.

Ruzena Sotnikova, Barbara Kaprinay, Jana Navarova.   

Abstract

The aim of the work was to study the effect of rosmarinic acid (RA) on markers of oxidative stress in rats with diabetes. Diabetes was induced by streptozotocin (STZ), RA was administered orally for ten weeks. Water consumption was measured daily. Ten weeks after the first RA administration, urine was collected over 15 hours. N-acetyl-β-D-glucosaminidase (NAGA) activity, levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) were determined in the pancreas, kidney, and plasma. RA administration to diabetic rats ameliorated markers of oxidative stress, as well as water consumption and urination. We assume that RA may mitigate STZ-induced diabetic manifestations by protecting rat tissues against damaging effect of free radicals.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26374995     DOI： 10.4149/gpb_2015025

Source DB:  PubMed          Journal:  Gen Physiol Biophys        ISSN： 0231-5882            Impact factor:   1.512


  6 in total

1.  Phytochemical Profiling, Antimicrobial and α-Glucosidase Inhibitory Potential of Phenolic-Enriched Extracts of the Aerial Parts from Echium humile Desf.: In Vitro Combined with In Silico Approach.

Authors:  Kaïss Aouadi; Hafedh Hajlaoui; Soumaya Arraouadi; Siwar Ghannay; Mejdi Snoussi; Adel Kadri
Journal:  Plants (Basel)       Date:  2022-04-21

2.  [Rosmarinic acid inhibits high glucose-induced cardiomyocyte hypertrophy by activating Parkin-mediated mitophagy].

Authors:  Jiayu Diao; Hongmou Zhao; Yujie Ning; Wenqi Han; Yi Wang; Gong Cheng; Xiling Shou; Hongjun You
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2020-11-30

3.  Effect of Rosmarinic Acid on the Serum Parameters of Glucose and Lipid Metabolism and Oxidative Stress in Estrogen-Deficient Rats.

Authors:  Maria Zych; Ilona Kaczmarczyk-Sedlak; Weronika Wojnar; Joanna Folwarczna
Journal:  Nutrients       Date:  2019-01-25       Impact factor: 5.717

Review 4.  The Use of Bioactive Compounds in Hyperglycemia- and Amyloid Fibrils-Induced Toxicity in Type 2 Diabetes and Alzheimer's Disease.

Authors:  Ancuta-Veronica Lupaescu; Monica Iavorschi; Mihai Covasa
Journal:  Pharmaceutics       Date:  2022-01-20       Impact factor: 6.321

Review 5.  Biomedical features and therapeutic potential of rosmarinic acid.

Authors:  Saba Noor; Taj Mohammad; Malik Abdul Rub; Ali Raza; Naved Azum; Dharmendra Kumar Yadav; Md Imtaiyaz Hassan; Abdullah M Asiri
Journal:  Arch Pharm Res       Date:  2022-04-07       Impact factor: 6.010

6.  Simultaneous characterization and quantification of 17 main compounds in Rabdosia rubescens by high performance liquid chromatography.

Authors:  Sen Guo; Xueqin Cui; Mi Jiang; Lu Bai; Xiao Tian; Tiantian Guo; Qingchao Liu; Li Zhang; Chi-Tang Ho; Naisheng Bai
Journal:  J Food Drug Anal       Date:  2016-07-26       Impact factor: 6.157
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.