| Literature DB >> 26374567 |
Tetsuro Sohda1, Kaoru Iwata2, Akira Anan2, Hideo Kunimoto2, Kaoru Yotsumoto2, Keiji Yokoyama2, Daisuke Morihara2, Yasuaki Takeyama2, Satoshi Shakado2, Akinobu Osame3, Shinichi Kora3, Jun Ohishi4, Yasushi Yamauchi4, Tomoaki Noritomi4, Kengo Yoshimitsu3, Yuichi Yamashita4, Shotaro Sakisaka4.
Abstract
A 73-year-old female with hepatocellular carcinoma (HCC) received percutaneous transhepatic portal vein embolization (PTPE) before extensive right lobe hepatectomy. Serum levels of des-gamma-carboxy-prothrombin (DCP) were increased and remained at a high level until hepatectomy. Immunohistochemical examination revealed that an increased expression of DCP was demonstrated not only in HCC tissues, but also in the non-cancerous liver of the right lobe, where portal blood flow was blocked off as a result of PTPE. The serum level of DCP is known to be greatly increased in patients with HCC accompanied by portal vein invasion. We speculate that this increased DCP level is caused by both increased DCP production in HCC tissue and the surrounding non-cancerous liver, where portal flow is blocked off as a result of portal invasion by HCC.Entities:
Keywords: Des-gamma-carboxy-prothrombin; Hepatocellular carcinoma; Immunohistochemistry; Percutaneous transhepatic portal vein embolization
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Year: 2015 PMID： 26374567 DOI： 10.1007/s12328-015-0603-x
Source DB: PubMed Journal: Clin J Gastroenterol ISSN： 1865-7265