| Literature DB >> 26374248 |
Jia-Lin Li1, Na Li1, Shan-Shan Xing1, Nan Zhang2, Ban-Ban Li1, Jian-Guang Chen1, Jong-Seog Ahn3, Long Cui4.
Abstract
New neo-lignan, (7S, 8R)-3-hydroxyl-4-methoxyl-balanophonin (1), together with seven known compounds (2-8) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. The structure of the new neo-lignan was elucidated with spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, the new compound (1) was found to exhibit selective inhibitory activity on PTP1B with IC50 value 15.2 ± 1.4 µM.Entities:
Keywords: Acanthopanax senticosus; Araliaceae; Neo-lignan; PTP1B
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Year: 2015 PMID： 26374248 DOI： 10.1007/s12272-015-0659-7
Source DB: PubMed Journal: Arch Pharm Res ISSN： 0253-6269 Impact factor: 4.946