| Literature DB >> 26373836 |
Kazusa Ishii1, Brenda M Birmann2, Xuehong Zhang2, Edward Giovannucci2,3,4, Kimberly A Bertrand2,3.
Abstract
Blood donation may influence subsequent NHL development via temporary immune system alterations. To test the hypothesis that frequent blood donation is associated with an increased risk of NHL and its most common histologic subtypes, this study followed 36 576 men in the Health Professionals Follow-up Study (HPFS), who provided information on frequency of blood donation in the past 30 years in 1992. This study confirmed 544 incident cases of NHL through 2010. Cox proportional hazards regression was used to calculate hazards ratios (HR) and 95% CI for the risk of all NHL and major NHL histologic subtypes associated with number of blood donations. In this prospective study, there was no significant evidence of an association between blood donation frequency and incidence of NHL (age-adjusted HR = 1.26, 95% CI = 0.94-1.68, comparing > 20 donations vs 0 donations over 30 years, p for trend = 0.18) or of any major NHL subtypes.Entities:
Keywords: Blood donation; epidemiology; non-Hodgkin lymphoma; risk
Mesh：
Year: 2015 PMID： 26373836 PMCID： PMC4834062 DOI： 10.3109/10428194.2015.1091928
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022